{
  "abstract": "Human acrocentric short arms harbor K111, an endogenous retrovirus that became an integral component of nucleolar organizer region (NOR)-associated architecture across all five acrocentric chromosome types. Here we combine complete human and primate genomes, haplotype-resolved population assemblies and parent-offspring trios to reconstruct its evolution and transmission. Predominantly full-length ancestral elements underwent human-specific expansion and remodeling, generating recurrent mosaics and individual-specific multicopy configurations. Population structural variation is concentrated in surrounding satellite landscapes rather than within K111-derived sequences themselves. Trio-resolved genomes reveal direct parental transmission, single-parent remodeling and, crucially, maternal-paternal remodeling in distinct configurations: large reciprocal domains with contrasting parental affinities and de novo sequence exchange within an offspring locus. Raw long reads support both maternal-paternal configurations. K111-derived loci associate with nucleolin-positive compartments. Together, these findings establish K111 as an evolutionarily dynamic component and molecular record of acrocentric NOR architecture, revealing unrecognized remodeling and sequence generation across human generations.",
  "abstract_shown": true,
  "affiliations": [
    "University of Alabama at Birmingham"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "M. WASEEM"
    },
    {
      "name": "A. Datta"
    },
    {
      "name": "A. Imtiaz"
    },
    {
      "name": "H. O Neill"
    },
    {
      "affs": [
        0
      ],
      "name": "R. C. Galindo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/52vcq0aebd5my.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.11.751073",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.11.751073v1.full",
  "id": "52vcq0aebd5my",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.11.751073v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "genetics"
    ],
    [
      "openalex",
      "1110|Chromosomal and Genetic Variations"
    ]
  ],
  "openalex": "W7212405134",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.11.751073v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/52vcq0aebd5my.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:43Z",
      "native_id": "10.64898/2026.09.11.751073",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.11.751073v3"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:genetics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Human-specific remodeling of an endogenous retrovirus shapes structural diversity at acrocentric nucleolar organizer regions",
  "title_text": "Human-specific remodeling of an endogenous retrovirus shapes structural diversity at acrocentric nucleolar organizer regions",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:38Z",
  "url": "https://research.draconitic.com/paper/52vcq0aebd5my",
  "venue": "bioRxiv",
  "versions": []
}