{
  "abstract": "Background: Functional recovery remains heterogeneous among patients with large-vessel occlusion stroke, even after successful reperfusion. Body temperature may constitute a potentially modifiable physiological factor associated with functional outcome. In particular, whether clinical factors, including baseline stroke severity, modify this temperature-outcome association remains uncertain.\n\nMethods: We retrospectively analyzed 219 patients with large-vessel occlusion acute ischemic stroke (LVO-AIS) who underwent EVT and achieved successful reperfusion, defined as a modified Thrombolysis in Cerebral Infarction score of 2b-3. Pre and post-EVT body temperatures were recorded. The primary outcome was favorable functional outcome, defined as a modified Rankin Scale (mRS) score of 0-2 at 90 days. Logistic regression analyses and exploratory subgroup analyses were performed to evaluate the association between body temperature and clinical outcomes.\n\nResults: Among the 219 included patients, 104 (47.5%) achieved favorable functional outcome at 90 days. Pre-EVT temperature was not significantly associated with functional outcome. In unadjusted analysis, each 1 °C increase in post-EVT temperature was associated with lower odds of favorable functional outcome (OR, 0.40; 95% CI, 0.20-0.79; P = 0.01) and higher odds of mortality (OR, 2.02; 95% CI, 1.11-3.66; P = 0.02). However, these associations were attenuated after multivariable adjustment (adjusted OR, 0.47; 95% CI, 0.19-1.15; P = 0.10; adjusted OR, 1.22; 95% CI, 0.49-3.02; P = 0.67). In exploratory subgroup analyses, a potential association between higher post-EVT temperature and lower odds of favorable outcome was observed in patients with baseline NIHSS ≤ 15 (adjusted OR, 0.29; 95% CI, 0.08-0.98; P = 0.047), although the interaction was not statistically significant ( P for interaction = 0.64).\n\nConclusion: In this exploratory study, body temperature was not independently associated with functional outcome in the overall cohort. Although a potential association between higher post-EVT temperature and unfavorable outcome was observed in patients with baseline NIHSS ≤ 15, the interaction was not significant. This finding is hypothesis-generating and warrants prospective validation with pre-specified subgroup analyses.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Graduate School, Dalian Medical University , ,",
    "Department of Neurology, General Hospital of Northern Theater Command , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hong-Ting Yan"
    },
    {
      "affs": [
        1
      ],
      "name": "Qi Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Lu Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Gao-Peng Xing"
    },
    {
      "affs": [
        1
      ],
      "name": "Jia-Qi Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yue Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Hui-Sheng Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/52x1q0fj3hber.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1910898",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690630/?tool=EBI",
  "id": "52x1q0fj3hber",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13690630",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7221191204",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690630/pdf/?tool=EBI",
  "pmcid": "PMC13690630",
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/52x1q0fj3hber.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "PMC:PMC13690630",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13690630"
    },
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1910898",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1910898/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Periprocedural body temperature and clinical outcomes after successful reperfusion in large vessel occlusion stroke",
  "title_text": "Periprocedural body temperature and clinical outcomes after successful reperfusion in large vessel occlusion stroke",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:16Z",
  "url": "https://research.draconitic.com/paper/52x1q0fj3hber",
  "venue": "Frontiers in neurology",
  "versions": []
}