{
  "abstract": "Glioblastoma (GBM) is an aggressive brain cancer in adults. Circadian rhythms regulate the sleep-wake cycle, which influences the body's physiological functions. Disruption of circadian rhythms is associated with certain neurological diseases, including GBM. The present narrative review highlights the relationship between circadian rhythm and GBM, the related mechanisms, and the therapeutic approaches against GBM. It also discusses how alterations in the expression of core circadian genes contribute to glioma genesis, especially GBM, and how restoring normal circadian gene function may suppress GBM progression. Additionally, chronotherapy could be considered a potential therapeutic approach for GBM. Aligning chemotherapy and radiotherapy with the internal clock of each patient may have the potential to increase the efficacy of treatments. A better understanding of the potential mechanisms underlying the association between circadian rhythm and GBM pathogenesis may help guide future circadian-based therapeutic approaches; however, further investigation is required.",
  "abstract_shown": true,
  "affiliations": [
    "Independent Researcher, Rasht 4173143385, Iran.",
    "Department of Neurophysiology, Institute of Physiology, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.",
    "Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark.",
    "Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, Denmark.",
    "Research Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, Denmark.",
    "Department of Neurology, Odense University Hospital, 5000 Odense, Denmark.",
    "Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
    "Department of Neurosurgery, Odense University Hospital, 5000 Odense, Denmark.",
    "Brain Research Interdisciplinary Guided Excellence (BRIDGE), University of Southern Denmark, 5230 Odense, Denmark.",
    "The Intervention Centre, Oslo University Hospital, 0372 Oslo, Norway.",
    "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0372 Oslo, Norway.",
    "Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife 50670-420, PE, Brazil."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Samaneh Ghorbani Shirkouhi"
    },
    {
      "affs": [
        1
      ],
      "name": "Farzin Kamari",
      "orcid": "0000-0003-4774-5168"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Poul Flemming Høilund-Carlsen",
      "orcid": "0000-0001-7420-2367"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Morten Blaabjerg",
      "orcid": "0000-0001-6007-1861"
    },
    {
      "affs": [
        6
      ],
      "name": "Abass Alavi",
      "orcid": "0000-0002-2442-7901"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Frantz Rom Poulsen",
      "orcid": "0000-0001-5715-6901"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Mona-Elisabeth R Revheim",
      "orcid": "0000-0003-3300-7420"
    },
    {
      "affs": [
        11
      ],
      "name": "Anderson Matheus Pereira da Silva",
      "orcid": "0009-0003-4789-6019"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Sasan Andalib"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/530secjwqeewx.bib",
  "cited_by": 0,
  "doi": "10.3390/clockssleep8040059",
  "fulltext_url": "https://europepmc.org/articles/PMC13692426",
  "id": "530secjwqeewx",
  "issns": [
    "2624-5175"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924735",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2807|Circadian rhythm and melatonin"
    ]
  ],
  "openalex": "W7214181052",
  "pdf_url": "https://europepmc.org/articles/PMC13692426?pdf=render",
  "pmcid": "PMC13692426",
  "pmid": "42924735",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/530secjwqeewx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42924735",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924735"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Circadian rhythm and melatonin",
      "subfield": "physiology"
    }
  ],
  "title": "The Circadian Clock in Glioblastoma: Mechanisms and Therapeutic Potential.",
  "title_text": "The Circadian Clock in Glioblastoma: Mechanisms and Therapeutic Potential.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/530secjwqeewx",
  "venue": "Clocks & sleep",
  "versions": []
}