{ "abstract": "The STRATIFY (Brain Network-Based Stratification of Reinforcement-Related Disorders) and ESTRA (Eating Disorders Stratification) studies were established as harmonised “sibling” cohorts to develop a mechanistically informed framework for stratifying psychiatric disorders. Here, we describe the study design, methodology, and cohort characteristics. Both studies investigate how network properties of brain structure and function, together with biological markers derived from blood-based genomics, epigenetics, and proteomics, relate to reinforcement-related behaviours that cut across major depressive disorder, alcohol use disorder, psychosis, and eating disorders. A further objective is to identify discriminative multimodal features that predict disease onset, symptom course, and functional outcomes, thereby supporting the development of targeted interventions. STRATIFY and ESTRA recruited 674 patients and 70 healthy controls aged 18–30 years (76% females), supplemented by 199 age- and sex-matched healthy controls from the population-based IMAGEN cohort assessed at the same sites using harmonised protocols. Multimodal assessment included structured clinical interviews, self-report measures, cognitive testing, biosamples for molecular analyses, and multimodal MRI (structural, diffusion, resting-state, and task-based fMRI). ESTRA participants additionally completed longitudinal follow-up, and all cohorts were assessed during the COVID-19 pandemic. STRATIFY and ESTRA together constitute a large-scale, open-science resource integrating multimodal brain, behavioural, and biological data across transdiagnostic patient cohorts in early adulthood. The anonymised dataset is available to the research community through managed access, supporting international collaboration and accelerating the development of mechanistically informed classification systems and predictive tools in psychiatry.", "abstract_shown": true, "affiliations": [ "Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany", "Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, SE5 8AF United Kingdom", "School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK", "Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany", "Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charitéplatz 1, Berlin, Germany", "Psychology Department, University of Southampton, Southampton, UK", "Oxford Institute of Clinical Psychology Training and Research, Oxford University, Oxford, UK", "Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, SE5 8AF United Kingdom", "Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland", "Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany", "NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France", "Institut National de la Santé et de la Recherche Médicale, UMR 992 INSERM, CEA, Faculté de médecine, Université Paris-Sud, Université Paris-Saclay, NeuroSpin, F-91191 Gif-sur-Yvette, France", "Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany", "Klinik für Kinder- und Jugendpsychiatrie- und Psychotherapie, Universitätsklinikum Heidelberg, Heidelberg, Germany", "Department of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, SE5 8AF UK", "South London and Maudsley NHS Foundation Trust, London, UK", "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK", "Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, UK", "School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland", "Centre for Population Neuroscience and Stratified Medicine (PONS), Institute for Science and Technology of Brain Inspired Intelligence and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China", "Department of Psychiatry, University of Cambridge, Cambridge, UK", "The German Center for Mental Health (DZPG), Charité Universitätsmedizin Berlin, Berlin, Germany" ], "article_type": "review article", "arxiv": null, "author_total": 27, "authors": [ { "affs": [ 0 ], "name": "Nilakshi Vaidya", "orcid": "0000-0002-4600-7158" }, { "affs": [ 1, 2 ], "name": "Zuo Zhang", "orcid": "0000-0002-6752-3434" }, { "affs": [ 1 ], "name": "Kofoworola Agunbiade" }, { "affs": [ 1 ], "name": "Georgina Keggin" }, { "affs": [ 0 ], "name": "Kebir Hedi" }, { "affs": [ 3, 4 ], "name": "Jeanne Winterer" }, { "affs": [ 1 ], "name": "Marina Bobou" }, { "affs": [ 5 ], "name": "John Broulidakis" }, { "affs": [ 1 ], "name": "Sinead King" }, { "affs": [ 1, 6 ], "name": "Lauren Robinson" }, { "affs": [ 5 ], "name": "Yuning Zhang" }, { "affs": [ 7 ], "name": "Gareth J. Barker", "orcid": "0000-0002-5214-7421" }, { "affs": [ 8 ], "name": "Arun L. Bokde", "orcid": "0000-0003-0114-4914" }, { "affs": [ 9 ], "name": "Rüdiger Brühl", "orcid": "0000-0003-0111-5996" }, { "affs": [ 10 ], "name": "Antoine Grigis" }, { "affs": [ 10, 11 ], "name": "Hervé Lemaître", "orcid": "0000-0002-5952-076X" }, { "affs": [ 0 ], "name": "Tristam Lett" }, { "affs": [ 12 ], "name": "Frauke Nees", "orcid": "0000-0002-7796-8234" }, { "affs": [ 11 ], "name": "Dimitri Papadopoulos", "orcid": "0000-0002-1242-8990" }, { "affs": [ 13 ], "name": "Luise Poustka" }, { "affs": [ 14, 15 ], "name": "Ulrike Schmidt" }, { "affs": [ 16 ], "name": "Julia Sinclair", "orcid": "0000-0002-1905-2025" }, { "affs": [ 17 ], "name": "Argyris Stringaris", "orcid": "0000-0002-6264-8377" }, { "affs": [ 18 ], "name": "Robert Whelan", "orcid": "0000-0002-2790-7281" }, { "affs": [ 4 ], "name": "Henrik Walter", "orcid": "0000-0002-9403-6121" }, { "affs": [ 1 ], "name": "Sylvane Desrivières", "orcid": "0000-0002-9120-7060" }, { "affs": [ 0, 19, 20, 21 ], "name": "Gunter Schumann", "orcid": "0000-0002-7740-6469" } ], "bibtex": "https://research.draconitic.com/paper/53h1pxgn320jm.bib", "cited_by": 0, "doi": "10.1038/s41380-026-03779-x", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736679/", "id": "53h1pxgn320jm", "issns": [ "1359-4184", "1476-5578" ], "landing_url": "https://doi.org/10.1038/s41380-026-03779-x", "language": "en", "licence": "CC-BY-4.0", "licence_label": "CC BY 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Perspective" ], [ "openalex", "2805|Functional Brain Connectivity Studies" ] ], "openalex": "W7170084948", "pdf_url": null, "pmcid": "PMC13736679", "pmid": "42486943", "published": "2026-07-22", "publisher": null, "ris": "https://research.draconitic.com/paper/53h1pxgn320jm.ris", "sources": [ { "first_seen": "2026-11-09T12:22:04Z", "native_id": "PMC13736679", "source": "pmc", "url": "https://doi.org/10.1038/s41380-026-03779-x" } ], "subjects": [ { "field": "biology", "origin": "openalex:2805|Functional Brain Connectivity Studies", "subfield": "neuroscience" } ], "title": "Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies", "title_text": "Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies", "type": "peer-reviewed", "updated_at": "2026-11-09T12:22:04Z", "url": "https://research.draconitic.com/paper/53h1pxgn320jm", "venue": "Molecular Psychiatry", "versions": [] }