{
  "abstract": "BACKGROUND: To identify the optimal radiotherapy planning technique that provides the best dosimetric outcomes in terms of target coverage and sparing of organs at risk (OAR) when using deep inspiration breath-holding (DIBH) for early left-sided breast cancer treatment. MATERIALS AND METHODS: Thirty patients with early-stage left-sided BC had previously been simulated and treated with DIBH using the active breathing coordinator (ABC) system. Each patient underwent replanning using 3D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) techniques with a prescription dose of 40.05 Gy over 15 fractions. The planning target volume (PTV) and OARs were evaluated using dose-volume histograms (DVH). Dosimetric parameters [V₉₅, D₉₈, D₅₀, D₂, V₁₀₇, conformity index (CI), homogeneity index (HI)], and OAR metrics for the heart, left anterior descending artery (LAD), lungs, and contralateral breast were analysed statistically. RESULTS: VMAT achieved the best PTV coverage and homogeneity (HI = 0.1). The mean heart dose was lowest for 3DCRT (1.9 Gy) and VMAT (2 Gy), whereas for the LAD VMAT achieved the lowest doses (Dₘₑₐₙ = 5.2 Gy; Dₘₐₓ = 17.3 Gy; p < 0.001). For the ipsilateral lung, 3DCRT offered superior low-dose sparing, while VMAT minimised high-dose exposure. Contralateral lung and breast doses were lowest with 3DCRT. CONCLUSIONS: VMAT offers superior target conformity and cardiac sparing, specifically for the LAD, whereas 3DCRT minimises contralateral organs and low-dose lung exposure. These findings highlight the necessity for personalised treatment, whether the priority is to limit cardiac toxicity or reduce low-dose exposure to the patient.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Biophysics, Department of Physics, Faculty of Science, Helwan University, Cairo, Egypt",
    "Medical Physics Department, Maadi Military Hospital and Air Force Specialized Hospital, Cairo, Egypt",
    "Clinical Oncology Department, Kasr Alainy Center of Clinical Oncology, Cairo University, Cairo, Egypt",
    "School of Applied Health Sciences, Badr University in Cairo (BUC), Badr City, Egypt"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yara G. Farid"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohamed S. Ibrahim"
    },
    {
      "affs": [
        0
      ],
      "name": "Medhat W. Shafaa"
    },
    {
      "affs": [
        2
      ],
      "name": "Noha A. Rahmoun"
    },
    {
      "affs": [
        3
      ],
      "name": "Magdy M. Khalil"
    },
    {
      "affs": [
        2
      ],
      "name": "Khalid A. Khalil"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/53r2z7h51rg5z.bib",
  "cited_by": 0,
  "doi": "10.5603/rpor.113430",
  "fulltext_url": "https://journals.viamedica.pl/rpor/article/view/113430",
  "id": "53r2z7h51rg5z",
  "issns": [
    "1507-1367",
    "2083-4640"
  ],
  "landing_url": "https://doi.org/10.5603/rpor.113430",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R895-920"
    ],
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "3108|Advanced Radiotherapy Techniques"
    ]
  ],
  "openalex": "W7168402299",
  "pdf_url": "https://journals.viamedica.pl/rpor/article/download/113430/90184",
  "pmcid": "PMC13743173",
  "pmid": "42997875",
  "published": "2026-11-01",
  "publisher": "Via Medica",
  "ris": "https://research.draconitic.com/paper/53r2z7h51rg5z.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T14:21:19Z",
      "native_id": "085a66f70e9b4982909ed07afa6abe31",
      "source": "doaj",
      "url": "https://doi.org/10.5603/rpor.113430"
    },
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42997875",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997875"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "openalex:3108|Advanced Radiotherapy Techniques",
      "subfield": "applied-instrumentation"
    }
  ],
  "title": "Comparison of different radiotherapy planning techniques in breast cancer using active breathing coordinator",
  "title_text": "Comparison of different radiotherapy planning techniques in breast cancer using active breathing coordinator",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/53r2z7h51rg5z",
  "venue": "Reports of Practical Oncology and Radiotherapy",
  "versions": []
}