{
  "abstract": "and its sulfur-oxidizing symbionts during sulfide shortage via in situ transplant experiments at the Haima cold seep. Transplanting clams to sulfide-depleted conditions (moderate at HM-3 and severe at HM-2) revealed distinct response patterns of host-symbiont interaction. Symbionts may mitigate sulfide loss by shifting from sulfide oxidation to thiosulfate oxidation, supported by thiosulfate generated through host sulfide detoxification pathways. Notably, symbiont abundance remained stable under moderate sulfide shortage (HM-3), accompanied by down-regulation of host endosomal maturation and fusion with lysosomes, potentially limiting symbiont turnover. Conversely, severe sulfide shortage (HM-2) was associated with up-regulation of lysosomal pathways and lower symbiont abundance. These results demonstrate tiered molecular adaptations-metabolic flexibility and shifts in symbiont dynamics-enabling holobiont resilience to spatially heterogeneous sulfide availability in deep-sea seeps, supporting ecosystem stability.",
  "abstract_shown": true,
  "affiliations": [
    "Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.",
    "Department of Ocean Science and Otto Poon Centre for Climate Resilience and Sustainability, The Hong Kong University of Science and Technology, Hong Kong SAR, China.",
    "Geomicrobiology Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.",
    "Centre of Deep-Sea Research, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.",
    "Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China.",
    "College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yi Lan",
      "orcid": "0000-0001-5501-1063"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Guoyong Yan",
      "orcid": "0000-0002-6603-6351"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Hao Wang",
      "orcid": "0000-0002-9435-5501"
    },
    {
      "affs": [
        4
      ],
      "name": "Kexin Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuxuan Lin",
      "orcid": "0000-0002-5651-8816"
    },
    {
      "affs": [
        2
      ],
      "name": "Tulika Bhardwaj",
      "orcid": "0000-0001-6382-2413"
    },
    {
      "affs": [
        3
      ],
      "name": "Chao Lian",
      "orcid": "0009-0009-5696-737X"
    },
    {
      "affs": [
        5
      ],
      "name": "Bing-Zheng Wu",
      "orcid": "0009-0006-4418-4384"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiying Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Casey R. J. Hubert",
      "orcid": "0000-0002-8691-8116"
    },
    {
      "affs": [
        4
      ],
      "name": "Jin Sun",
      "orcid": "0000-0001-8002-6881"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pei-Yuan Qian",
      "orcid": "0000-0003-4074-9078"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/54jtcvz88hbkr.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aed8728",
  "fulltext_url": null,
  "id": "54jtcvz88hbkr",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aed8728",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1910|Marine Biology and Ecology Research"
    ]
  ],
  "openalex": "W7215954163",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/54jtcvz88hbkr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aed8728",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aed8728"
    }
  ],
  "subjects": [
    {
      "field": "earth",
      "origin": "openalex:1910|Marine Biology and Ecology Research",
      "subfield": "oceanography"
    }
  ],
  "title": "In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations",
  "title_text": "In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/54jtcvz88hbkr",
  "venue": "Science Advances",
  "versions": []
}