{
  "abstract": "Objective\n\nObjective: Chronic daily headache (CDH) is a prevalent neuropsychiatric condition. We aimed to quantify concurrent Axis I psychiatric comorbidity and personality pathology in CDH versus matched controls and identify factors independently associated with headache-related disability.Method\n\nThis hospital-based matched-control study was conducted at a tertiary teaching hospital in Faridabad (Delhi-NCR), India. Seventy-five ICHD-3-confirmed CDH patients and 75 age- and sex-matched controls completed the Mini International Neuropsychiatric Interview (MINI v5.0), Millon Clinical Multiaxial Inventory-III (MCMI-III; personality, base rate ≥ 85), and Headache Impact Test-6 (HIT-6). Multivariable binary logistic regression identified independent cross-sectional associates of high disability (HIT-6 ≥ 56). STROBE guidelines were followed.Results\n\nPsychiatric comorbidity was present in 60.0% of cases versus 13.3% of controls (χ² = 33.19, p < .001, V = 0.47), predominantly depression (33.3%) and anxiety (28.0%). Personality disorders occurred in 56.0% versus 18.7% (χ² = 22.27, p < .001, V = 0.39). An exploratory Cluster A signal was observed for paranoid (10.7% vs. 0%, p = .006) and schizoid (10.7% vs. 1.3%, p = .034) pathology; small cells render these findings hypothesis-generating. Psychiatric comorbidity was the strongest independent associate of high disability (adjusted OR=10.82, 95% CI 3.03-38.60, p < .001), exceeding migraine subtype (OR=5.12, p = .037). Personality disorder showed a non-significant trend (OR=3.30, p = .066; Nagelkerke R² = 0.482).Conclusions\n\nPsychiatric comorbidity was strongly and independently associated with disability in CDH, supporting integrated psychiatric screening. The exploratory Cluster A signal warrants replication in adequately powered prospective studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry, ESIC Medical College and Hospital, Faridabad - 121001, India."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vikram Singh"
    },
    {
      "affs": [
        0
      ],
      "name": "Sunil Goyal"
    },
    {
      "affs": [
        0
      ],
      "name": "Ankur Sachdeva"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/553v8eqkvtqy2.bib",
  "cited_by": 0,
  "doi": "10.36131/cnfioritieditore20260503",
  "fulltext_url": "https://europepmc.org/articles/PMC13684848",
  "id": "553v8eqkvtqy2",
  "issns": [
    "1724-4935",
    "2385-0787"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909916",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Migraine and Headache Studies"
    ]
  ],
  "openalex": "W7223379069",
  "pdf_url": "https://europepmc.org/articles/PMC13684848?pdf=render",
  "pmcid": "PMC13684848",
  "pmid": "42909916",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/553v8eqkvtqy2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42909916",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909916"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Migraine and Headache Studies",
      "subfield": "psychiatry"
    }
  ],
  "title": "Psychiatric Comorbidity Outweighs Headache Subtype As A Predictor Of Disability In Chronic Daily Headache: A Matched-Control Study.",
  "title_text": "Psychiatric Comorbidity Outweighs Headache Subtype As A Predictor Of Disability In Chronic Daily Headache: A Matched-Control Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/553v8eqkvtqy2",
  "venue": "Clinical neuropsychiatry",
  "versions": []
}