{
  "abstract": "Durable left ventricular assist devices (LVADs) have become an established therapy for selected patients with advanced heart failure as bridge-to-transplant or destination therapy. Despite major progress in continuous-flow pump design and perioperative care, long-term benefit remains constrained by a recurrent burden of right heart failure, aortic regurgitation, pump thrombosis, stroke, bleeding, infection, and end-organ dysfunction. Because these events often arise from the interaction of altered hemodynamics, hemocompatibility-related injury, chronic antithrombotic exposure, and the practical complexity of longitudinal device care, a complication-centered management framework is clinically useful. This contemporary narrative review focuses on actionable prevention, surveillance, and treatment strategies for the major complications encountered during durable LVAD support. Rather than providing a broad device-oriented overview, we emphasize clinically relevant decision points across the perioperative and long-term course, including right ventricular protection, antithrombotic balance, structured monitoring for aortic regurgitation and hemolysis, prevention of driveline infection, and multidisciplinary outpatient follow-up. By organizing current evidence around practical management pathways, this review aims to support earlier recognition of adverse events and more durable long-term support.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiovascular Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital), Wuhu, Anhui, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wei Yong Sheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Tian Sheng Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "You Shi Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hussain Asif"
    },
    {
      "affs": [
        0
      ],
      "name": "Saifane Zakaria"
    },
    {
      "affs": [
        0
      ],
      "name": "Da Fa Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/557rsdq9fsx7f.bib",
  "cited_by": 0,
  "doi": "10.14740/cr2283",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719642/?tool=EBI",
  "id": "557rsdq9fsx7f",
  "issns": [
    "1923-2829",
    "1923-2837"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13719642",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2204|Mechanical Circulatory Support Devices"
    ]
  ],
  "openalex": "W7223475398",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719642/pdf/?tool=EBI",
  "pmcid": "PMC13719642",
  "pmid": "42964425",
  "published": "2026-10-24",
  "publisher": "Elmer Press",
  "ris": "https://research.draconitic.com/paper/557rsdq9fsx7f.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13719642",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719642"
    },
    {
      "first_seen": "2026-11-02T12:23:34Z",
      "native_id": "PMC13719642",
      "source": "pmc",
      "url": "https://doi.org/10.14740/cr2283"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Clinically Actionable Prevention and Management of Major Complications During Durable Left Ventricular Assist Device Support: A Contemporary Narrative Review",
  "title_text": "Clinically Actionable Prevention and Management of Major Complications During Durable Left Ventricular Assist Device Support: A Contemporary Narrative Review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:40Z",
  "url": "https://research.draconitic.com/paper/557rsdq9fsx7f",
  "venue": "Cardiology research",
  "versions": []
}