{
  "abstract": "Herein, I report a unique coupling method for insoluble pteroic acid. Tetraalkylammonium hydroxide effectively enabled solubilization, efficient coupling with an amine, and an easy workup process to produce folate-conjugated peptides. The generality and versatility were confirmed through coupling studies of several amino acids, demonstrating its applicability to the synthesis of various folate and pteroate conjugates.",
  "abstract_shown": true,
  "affiliations": [
    "NIPPON SHOKUBAI CO., LTD, Nishi Otabi-cho, Suita, Osaka, 564-0034"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuya Asahina",
      "orcid": "0000-0001-6814-245X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/55c6cctbfwrs1.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008525/v1",
  "fulltext_url": null,
  "id": "55c6cctbfwrs1",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008525/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Chemical Synthesis and Analysis"
    ]
  ],
  "openalex": "W7212047844",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008525/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/55c6cctbfwrs1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.26434/chemrxiv.15008525",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008525/v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Chemical Synthesis and Analysis",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Coupling Insoluble Pteroic Acid Using Quaternary Ammonium Salts: Synthesis of a Peptide Bearing a Folic Acid Moiety",
  "title_text": "Coupling Insoluble Pteroic Acid Using Quaternary Ammonium Salts: Synthesis of a Peptide Bearing a Folic Acid Moiety",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/55c6cctbfwrs1",
  "venue": "ChemRxiv",
  "versions": []
}