{
  "abstract": "Patients with advanced endometrial cancer (EC) have a poor prognosis and limited therapeutic options after failure of prior systemic therapy. In this multi-cohort Phase II study (ETER200), patients with metastatic or recurrent EC who had received at least one chemotherapy regimen were enrolled. Based on MSI/MMR status, patients received benmelstobart plus anlotinib (Cohort 1), benmelstobart (Cohort 2), or anlotinib (Cohort 3) every 3 weeks. Primary endpoint was objective response rate (ORR) assessed by independent review committee (IRC) per RECIST v1.1. Here, the results of Cohort 1 expansion stage were reported. As of May 9, 2024, 85 of the 107 non-MSI-H/pMMR EC patients enrolled in Cohort 1 constituted the expansion stage population for primary efficacy analysis. The IRC-assessed ORR was 34.1% (95% CI, 24.2-45.2), with a median duration of response of 15.2 months (95% CI, 6.9-not evaluable). Median progression-free and overall survival were 8.8 months (95% CI, 5.8-15.2) and 21.8 months (95% CI, 19.5-29.1), respectively. Grade ≥ 3 treatment-related adverse events occurred in 69.2% of patients, most commonly hypertension (21.2%) and palmar-plantar erythrodysesthesia syndrome (9.4%). Overall, benmelstobart plus anlotinib showed promising anti-tumor activity and an acceptable safety profile in advanced non-MSI-H/pMMR EC, supporting further evaluation of this combination in randomized Phase III studies. Trial Registration: ClinicalTrials.gov, NCT04574284.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gynecologic Oncology Fudan University Shanghai Cancer Center Shanghai China.",
    "Department of Gynecology and Oncology Obstetrics & Gynecology Hospital of Fudan University Shanghai China.",
    "Department of Obstetrics and Gynecology Shanghai Tenth People's Hospital Shanghai China.",
    "Department of Gynecologic Oncology Tianjin Cancer Hospital Tianjin China.",
    "Gynecologic Oncology Center Chongqing University Cancer Hospital Chongqing China.",
    "Department of Obstetrics and Gynecology First Affiliated Hospital of Xi'an Jiaotong University Xi'an China.",
    "Department of Gynecology Yantai Yuhuangding Hospital Yantai China.",
    "Fifth Department of Obstetrics and Gynecology Liaoning Cancer Hospital & Institute Shenyang China.",
    "Department of Gynecology and Oncology Tianjin Central Hospital of Gynecology Obstetrics Tianjin China.",
    "Department of Gynecology and Oncology Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou China.",
    "Department of Gynecology and Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China.",
    "Department of Gynecology Linyi Cancer Hospital Linyi China.",
    "Department of Medical Oncology Affiliated Hospital of Hebei University Baoding China.",
    "Department of Oncology Weifang People's Hospital Weifang China.",
    "Department of Gynecologic Oncology and Radiation Therapy Zhejiang Cancer Hospital Hangzhou China.",
    "Department of Gynecology and Oncology Guangxi Medical University Cancer Hospital Nanning China.",
    "Department of Obstetrics and Gynecology Beijing Chao-Yang Hospital Capital Medical University Beijing China.",
    "Department of Oncology Beijing Luhe Hospital Capital Medical University Beijing China.",
    "Department of Oncology Meizhou People's Hospital Meizhou China.",
    "Department of Oncology Affiliated Hospital of Jining Medical University Jining China.",
    "Department of Obstetrics and Gynecology The First Affiliated Hospital of USTC Anhui Provincial Hospital Hefei China.",
    "Department of Medical Oncology The First Affiliated Hospital of Shihezi University School of Medicine Shihezi China.",
    "Department of Gynecology Sun Yat-Sen University Cancer Center Guangzhou China.",
    "Fifth Department of Gynecologic Oncology Hunan Cancer Hospital Changsha China.",
    "Department of Obstetrics and Gynecology Second Hospital of Shanxi Medical University Taiyuan China.",
    "Department of Obstetrics and Gynecology The First Affiliated Hospital Sun Yat-Sen University Guangzhou China.",
    "Department of Oncology Binzhou Medical University Hospital Binzhou China.",
    "Department of Obstetrics and Gynecology Nanjing Drum Tower Hospital Nanjing China.",
    "Department of Gynecologic Oncology Qingdao Central Medical Group Qingdao China.",
    "Department of Obstetrics and Gynecology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.",
    "Department of Gynecology Gansu Provincial Maternity and Child-Care Hospital Lanzhou China.",
    "Department of Radiation Oncology Taizhou Hospital of Zhejiang Province Taizhou China.",
    "Department of Gynecology and Oncology Henan Cancer Hospital Zhengzhou China.",
    "Department of Oncology The Second Hospital of Anhui Medical University Hefei China.",
    "Department of Gynecology and Oncology Jiangsu Cancer Hospital Nanjing China.",
    "Department of Gynecology Affiliated Tumor Hospital of Xinjiang Medical University Urumqi China.",
    "Department of Obstetrics and Gynecology Xi'an People Hospital (Xi'an Fourth Hospital) Xi'an China.",
    "Department of Gynecology Qilu Hospital of Shandong University Jinan China.",
    "Department of Obstetrics and Gynecology Beijing Tsinghua Changgung Hospital Beijing China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 41,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shanhui Liang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Xiaojun Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Ke Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Dong Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Ruifang An"
    },
    {
      "affs": [
        6
      ],
      "name": "Jianqing Hou"
    },
    {
      "affs": [
        6
      ],
      "name": "Ying Yang"
    },
    {
      "affs": [
        7
      ],
      "name": "Danbo Wang"
    },
    {
      "affs": [
        8
      ],
      "name": "Pengpeng Qu"
    },
    {
      "affs": [
        9
      ],
      "name": "Bingzhong Zhang"
    },
    {
      "affs": [
        10
      ],
      "name": "Wei Duan"
    },
    {
      "affs": [
        11
      ],
      "name": "Xiumin Li"
    },
    {
      "affs": [
        12
      ],
      "name": "Aimin Zang"
    },
    {
      "affs": [
        13
      ],
      "name": "Guohua Yu"
    },
    {
      "affs": [
        14
      ],
      "name": "Hanmei Lou"
    },
    {
      "affs": [
        15
      ],
      "name": "Desheng Yao"
    },
    {
      "affs": [
        16
      ],
      "name": "Shuzhen Wang"
    },
    {
      "affs": [
        17
      ],
      "name": "Dong Yan"
    },
    {
      "affs": [
        18
      ],
      "name": "Liang Li"
    },
    {
      "affs": [
        19
      ],
      "name": "Xiaowei Liu"
    },
    {
      "affs": [
        20
      ],
      "name": "Weidong Zhao"
    },
    {
      "affs": [
        20
      ],
      "name": "Zhengzheng Chen"
    },
    {
      "affs": [
        21
      ],
      "name": "Jing Fei"
    },
    {
      "affs": [
        22
      ],
      "name": "Jundong Li"
    },
    {
      "affs": [
        23
      ],
      "name": "Jing Wang"
    },
    {
      "affs": [
        24
      ],
      "name": "Zhilian Wang"
    },
    {
      "affs": [
        25
      ],
      "name": "Shuzhong Yao"
    },
    {
      "affs": [
        26
      ],
      "name": "Fangling Ning"
    },
    {
      "affs": [
        27
      ],
      "name": "Huaijun Zhou"
    },
    {
      "affs": [
        28
      ],
      "name": "Li Sun"
    },
    {
      "affs": [
        29
      ],
      "name": "Lingya Pan"
    },
    {
      "affs": [
        30
      ],
      "name": "Qing Liu"
    },
    {
      "affs": [
        31
      ],
      "name": "Haihua Yang"
    },
    {
      "affs": [
        32
      ],
      "name": "Li Wang"
    },
    {
      "affs": [
        33
      ],
      "name": "Mingjun Zhang"
    },
    {
      "affs": [
        34
      ],
      "name": "Xiaoxiang Chen"
    },
    {
      "affs": [
        35
      ],
      "name": "Jianlin Yuan"
    },
    {
      "affs": [
        36
      ],
      "name": "Xinwen Zhang"
    },
    {
      "affs": [
        37
      ],
      "name": "Youzhong Zhang"
    },
    {
      "affs": [
        38
      ],
      "name": "Qinping Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaohua Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/55ffzrwj6nee5.bib",
  "cited_by": 0,
  "doi": "10.1002/mco2.71081",
  "fulltext_url": "https://europepmc.org/articles/PMC13686440",
  "id": "55ffzrwj6nee5",
  "issns": [
    "2688-2663"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910366",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7223132457",
  "pdf_url": "https://europepmc.org/articles/PMC13686440?pdf=render",
  "pmcid": "PMC13686440",
  "pmid": "42910366",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/55ffzrwj6nee5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42910366",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910366"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Efficacy and Safety of Benmelstobart Plus Anlotinib in Advanced Endometrial Cancer: Results of a Multi-Cohort, Phase II Study (ETER200).",
  "title_text": "Efficacy and Safety of Benmelstobart Plus Anlotinib in Advanced Endometrial Cancer: Results of a Multi-Cohort, Phase II Study (ETER200).",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/55ffzrwj6nee5",
  "venue": "MedComm",
  "versions": []
}