{
  "abstract": "Currently, no generalizable tools exist for predicting the impact of interventions on aging using gene expression changes. Here, we build a model for predicting potential geroprotectors by deconstructing the aging transcriptome into coexpression modules and identifying those modulated by life span–extending interventions in Caenorhabditis elegans ( C. elegans ). Many of these modules exhibited adaptive changes during aging that are linked to longevity. Using these longevity-associated modules, we predicted and validated 10 compounds (7 previously unreported) that significantly extended life span in C. elegans . RNA sequencing analysis of two top candidates also showed targeted modulation of our longevity-associated modules. We identified conservation of several modules in mice that were also correlated with frailty. Together, our findings demonstrate that beneficial transcriptomic adaptations occur during aging and that targeting longevity-associated modules offers a framework for geroprotector discovery.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.",
    "Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.",
    "Centre for Healthy Longevity, National University Health System, Singapore 159964, Singapore.",
    "Science Divisions, Yale, NUS College, Singapore 138527, Singapore.",
    "Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Weihan Huai",
      "orcid": "0009-0003-8565-8249"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Li-Fang Ng",
      "orcid": "0000-0002-0792-6864"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jasinda H. Lee",
      "orcid": "0000-0001-7779-8135"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Qingyun Wang",
      "orcid": "0000-0002-9765-2544"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Kamil Pabis"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhuangli Yee",
      "orcid": "0000-0002-0257-5364"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Shivaanisha Raventhiran",
      "orcid": "0009-0006-4046-1487"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shou-Ping Guan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shermaine Thein"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Stephen Dinesh Raj",
      "orcid": "0000-0003-2927-5000"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Jerald Tan",
      "orcid": "0000-0002-3462-3455"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Angelica Faye Ga"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Sharah Mae Capinpin",
      "orcid": "0000-0001-6759-1712"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Diogo Barardo",
      "orcid": "0000-0001-6177-0728"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Qing Zhang",
      "orcid": "0009-0005-3509-8196"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zongmin Liu",
      "orcid": "0000-0002-5871-5434"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Esther Wong",
      "orcid": "0000-0003-2421-7346"
    },
    {
      "affs": [
        0,
        1,
        2,
        4
      ],
      "name": "Brian Keith Kennedy",
      "orcid": "0000-0002-5754-1874"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Jan Gruber",
      "orcid": "0000-0003-3329-3789"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/55w50ye72vx9t.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aee3657",
  "fulltext_url": null,
  "id": "55w50ye72vx9t",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aee3657",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7214916302",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/55w50ye72vx9t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aee3657",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aee3657"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "Predicting and finding geroprotective compounds through modulating conserved longevity–associated aging modules",
  "title_text": "Predicting and finding geroprotective compounds through modulating conserved longevity–associated aging modules",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/55w50ye72vx9t",
  "venue": "Science Advances",
  "versions": []
}