{
  "abstract": "Small interfering RNAs (siRNAs) were prepared with vinyl nucleobases and imperfect duplex reaction sites that enable selective inverse electron-demand Diels–Alder (IEDDA) reactions with tetrazines in living cells. These bioorthogonal reactions attenuate gene silencing of both reporter and endogenous genes, establishing a small-molecule strategy for deactivating siRNA activity.",
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  "affiliations": [
    "Department of Chemistry, McGill University Montréal H3A 0B8 Canada",
    "Department of Pharmacology and Therapeutics, McGill University Montréal H3G 1Y6 Canada"
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  "arxiv": null,
  "author_total": 4,
  "authors": [
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      "name": "Kaifeng Zhao",
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      "name": "Loïc Courville-Fortin"
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      "name": "Nathan W. Luedtke",
      "orcid": "0000-0003-2214-8818"
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  "bibtex": "https://research.draconitic.com/paper/55yrpq2h69zrv.bib",
  "cited_by": 0,
  "doi": "10.1039/d6cb00284f",
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  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725365/pdf/?tool=EBI",
  "pmcid": "PMC13725365",
  "pmid": "42973900",
  "published": "2026-10-12",
  "publisher": "Royal Society of Chemistry",
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  "subjects": [
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      "origin": "openalex:1605|Click Chemistry and Applications",
      "subfield": "organic"
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  "title": "Deactivating siRNA activity with bioorthogonal inverse-electron-demand Diels–Alder chemistry",
  "title_text": "Deactivating siRNA activity with bioorthogonal inverse-electron-demand Diels–Alder chemistry",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:39Z",
  "url": "https://research.draconitic.com/paper/55yrpq2h69zrv",
  "venue": "RSC chemical biology",
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}