{
  "abstract": "Regulatory T cells (Tregs) play a critical role in shaping the immunosuppressive tumor microenvironment in gastric cancer and have attracted increasing attention in the context of immunotherapy. This study aimed to provide a comprehensive bibliometric overview of global research on Tregs in gastric cancer from 2005 to 2025 and to identify evolving thematic trends. Publications were retrieved from the Web of Science Core Collection using a predefined search strategy. A total of 464 English-language publications, including articles and reviews, were included. Bibliometric analyses were performed using the bibliometrix R package, VOSviewer, and CiteSpace to assess publication trends, country and institutional productivity, collaboration patterns, keyword co-occurrence, and citation bursts. The 50 most-cited publications were further analyzed to identify high-impact thematic focuses. Annual publication output demonstrated a sustained increase over the past two decades, with notable growth after 2015. China contributed the highest number of publications, Japan showed the highest citation impact per article, and the United States occupied a central position in international collaboration networks. Keyword clustering identified three major research themes: Treg biology and prognosis, immunotherapy-related research, and Helicobacter pylori-associated immunomodulation. Temporal and citation-burst analyses revealed an increasing emphasis on immune checkpoint blockade and translational immunotherapy in recent years. This bibliometric study systematically characterizes the global research landscape of Tregs in gastric cancer and highlights a progressive shift from mechanistic and prognostic studies toward immunotherapy-oriented and translational research. The findings also identify key future priorities, including standardized characterization of Treg subsets, validation of Treg-related biomarkers, and integration of spatial and multi-omics approaches with patient-level clinical outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Jiangxi University of Chinese Medicine, Nanchang, China.",
    "Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Houshu Tu"
    },
    {
      "affs": [
        0
      ],
      "name": "Menglin Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Panpan Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jing Hong"
    },
    {
      "affs": [
        1
      ],
      "name": "Ling He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5696kpdp5ft7x.bib",
  "cited_by": 0,
  "doi": "10.21037/tcr-2026-0878",
  "fulltext_url": "https://europepmc.org/articles/PMC13743207",
  "id": "5696kpdp5ft7x",
  "issns": [
    "2218-676X",
    "2219-6803"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997897",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3309|scientometrics and bibliometrics research"
    ]
  ],
  "openalex": "W7223340973",
  "pdf_url": "https://europepmc.org/articles/PMC13743207?pdf=render",
  "pmcid": "PMC13743207",
  "pmid": "42997897",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5696kpdp5ft7x.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42997897",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997897"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Global trends and translational evolution of regulatory T cell research in gastric cancer: a bibliometric mapping (2005-2025).",
  "title_text": "Global trends and translational evolution of regulatory T cell research in gastric cancer: a bibliometric mapping (2005-2025).",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/5696kpdp5ft7x",
  "venue": "Translational cancer research",
  "versions": []
}