{
  "abstract": "Background/Objectives: Short-term prognostication remains challenging in critically ill patients with neoplasia. We aimed to retrospectively evaluate the clinical, oncological, and hematological factors associated with in-hospital mortality and its timing in 120 patients with neoplasia admitted to intensive care unit (ICU). Methods: This retrospective cohort included 120 patients admitted to an intensive care unit (ICU). In-hospital mortality was analyzed using Firth penalized logistic regression with adjustment for Acute Physiology and Chronic Health Evaluation II (APACHE II) scores recorded at ICU admission. Time to death was analyzed using Cox regression and Fine–Gray competing-risk regression. Predictive performance was internally validated using 1000 bootstrap resamples, with calibration and exploratory decision-curve analyses. Results: Mortality was 80.0%. After APACHE II adjustment, hepatic metastases remained associated with mortality (adjusted odds ratio [aOR] 7.87, 95% confidence interval [CI] 2.41–29.44), whereas platelet count was inversely associated (aOR 0.82 per 50 × 109/L, 95% CI 0.69–0.94). Neutrophil-to-lymphocyte ratio (NLR) was not significantly associated with binary mortality. In APACHE II-adjusted Fine–Gray analysis, NLR (subdistribution hazard ratio [sHR] 1.20 per doubling, 95% CI 1.03–1.40) and platelet count (sHR 0.90, 95% CI 0.84–0.97) were associated with the cumulative incidence of death. Adding platelet count increased the optimism-corrected area under the receiver operating characteristic curve (AUROC) from 0.743 to 0.799 in the original clinical model (ΔAUROC 0.056, 95% CI 0.002–0.146); after APACHE II adjustment, the gain was uncertain (0.745 to 0.793; ΔAUROC 0.048, 95% CI −0.0003–0.128). Conclusions: Hepatic metastases and platelet count retained prognostic associations after severity adjustment.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galați, 800008 Galați, Romania",
    "Comrat State University, MD-3805 Comrat, Moldova",
    "Faculty of Medicine and Biological Sciences, ‘Ștefan cel Mare’ University, 720229 Suceava, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Valeriu Plătică"
    },
    {
      "affs": [
        0
      ],
      "name": "Iulia Chiscop"
    },
    {
      "affs": [
        1
      ],
      "name": "Adina Plătică"
    },
    {
      "affs": [
        0
      ],
      "name": "Magdalena Miulescu",
      "orcid": "0000-0002-0052-2795"
    },
    {
      "affs": [
        0
      ],
      "name": "Corina-Cecilia Manole Pălivan"
    },
    {
      "affs": [
        0
      ],
      "name": "Anamaria Hărăbor"
    },
    {
      "affs": [
        0
      ],
      "name": "Dorel Firescu"
    },
    {
      "affs": [
        0
      ],
      "name": "Mihaela Lungu"
    },
    {
      "affs": [
        2
      ],
      "name": "Ingrid-Andrada Vasilache",
      "orcid": "0000-0002-4718-392X"
    },
    {
      "affs": [
        0
      ],
      "name": "Laura-Florentina Rebegea"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/56a9b78ksn34f.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218669",
  "fulltext_url": null,
  "id": "56a9b78ksn34f",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8669",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/56a9b78ksn34f.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:41Z",
      "native_id": "10.3390/jcm15218669",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8669"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Clinical, Oncological, and Hematological Determinants of In-Hospital Mortality in Critically Ill Patients with Advanced Neoplasia: A Retrospective Cohort Study",
  "title_text": "Clinical, Oncological, and Hematological Determinants of In-Hospital Mortality in Critically Ill Patients with Advanced Neoplasia: A Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/56a9b78ksn34f",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}