{
  "abstract": "Unicameral bone cysts (UBCs) are benign, fluid-filled lesions most commonly affecting the proximal humerus in children. Malignant transformation of a histologically confirmed UBC is extraordinarily rare, with only isolated cases reported in the literature. A 12-year-old girl developed high-grade telangiectatic osteosarcoma of the left proximal humerus 18 months after curettage and injection of a bone substitute for a biopsy-proven UBC. She presented with new-onset shoulder pain, and further imaging and biopsy confirmed telangiectatic osteosarcoma. She underwent neoadjuvant chemotherapy followed by wide resection and alloprosthetic hemiarthroplasty reconstruction. This rare case highlights that new or recurrent symptoms after treatment of benign bone tumors warrant immediate re-evaluation, as malignant transformation, though rare, can occur.",
  "abstract_shown": true,
  "affiliations": [
    "Montefiore Einstein, Department of Orthopaedic Surgery, Bronx, New York, USA.",
    "Department of Orthopaedic Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.",
    "Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, Florida, USA.",
    "Department of Pathology and Laboratory Medicine, University of Miami Hospital, Miami, Florida, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jean G Louka",
      "orcid": "0000-0002-0741-544X"
    },
    {
      "affs": [
        1
      ],
      "name": "Eric Kholodovsky",
      "orcid": "0009-0005-5542-6564"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Julien Montreuil",
      "orcid": "0000-0002-4893-7455"
    },
    {
      "affs": [
        3
      ],
      "name": "Andrew E Rosenberg",
      "orcid": "0000-0002-4536-8824"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Taha Aksoy",
      "orcid": "0000-0002-8900-9858"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "H Thomas Temple",
      "orcid": "0009-0005-7115-073X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/56bfndsskxecq.bib",
  "cited_by": 0,
  "doi": "10.13107/jocr.2026.v16.i11.8372",
  "fulltext_url": "https://europepmc.org/articles/PMC13740996",
  "id": "56bfndsskxecq",
  "issns": [
    "2250-0685",
    "2321-3817"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997095",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2732|Bone Tumor Diagnosis and Treatments"
    ]
  ],
  "openalex": "W7225565606",
  "pdf_url": "https://europepmc.org/articles/PMC13740996?pdf=render",
  "pmcid": "PMC13740996",
  "pmid": "42997095",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/56bfndsskxecq.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42997095",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997095"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Bone Tumor Diagnosis and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Telangiectatic Osteosarcoma Arising in a Treated Unicameral Bone Cyst of the Proximal Humerus: A Case Report.",
  "title_text": "Telangiectatic Osteosarcoma Arising in a Treated Unicameral Bone Cyst of the Proximal Humerus: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/56bfndsskxecq",
  "venue": "Journal of orthopaedic case reports",
  "versions": []
}