{
  "abstract": "Amyloid-beta (A{beta}) accumulation in the brain is linked to Alzheimer's disease. In healthy individuals, A{beta} rises during wakefulness and is cleared during sleep, yet the effects of sleep disturbances on the A{beta} dynamics are unclear. We developed a model, incorporating brain, cerebrospinal fluid (CSF), and plasma, to investigate the A{beta} dynamics along the sleep-wake cycles. The model reproduces the experimentally observed 24-hour A{beta}42 oscillations in CSF (660-760 pg/mL) and plasma (15-19 pg/mL) and predicts brain A{beta} dynamics. Indwelling lumbar catheter data show elevated CSF A{beta}42 levels on the second morning after a full night of sleep compared to first morning. The model predicts this increased level is due to repeated CSF sampling, which affects A{beta} levels through pressure-mediated changes in CSF, impaired sleep associated clearance, or their synergistic effect. These findings provide a framework for understanding A{beta} regulation, highlighting sleep's protective role and the need for non-invasive measurement approaches.",
  "abstract_shown": true,
  "affiliations": [
    "School of Physics, The University of Sydney, Camperdown, Australia"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. Sangeet"
    },
    {
      "name": "C. L. Phillips"
    },
    {
      "name": "C. M. Hoyos"
    },
    {
      "name": "A. L. D'Rozario"
    },
    {
      "name": "B. P. Lucey"
    },
    {
      "name": "S. Postnova"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/56k9amjpn8j6e.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.07.749991",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749991v1.full",
  "id": "56k9amjpn8j6e",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749991v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7212552522",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749991v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/56k9amjpn8j6e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:20Z",
      "native_id": "10.64898/2026.09.07.749991",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749991v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Quantitative Modelling of Amyloid-β Dynamics in Brain, CSF, and Plasma During Sleep and Wakefulness",
  "title_text": "Quantitative Modelling of Amyloid-β Dynamics in Brain, CSF, and Plasma During Sleep and Wakefulness",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:20Z",
  "url": "https://research.draconitic.com/paper/56k9amjpn8j6e",
  "venue": "bioRxiv",
  "versions": []
}