{
  "abstract": "Background: Temocillin is a narrow-spectrum β-lactam with activity against extended-spectrum β-lactamase (ESBL)- and AmpC-producing Enterobacterales and represents a potential carbapenem-sparing option, especially for urinary tract infections (UTIs). This multicentre study evaluated the real-world use, clinical outcomes, and tolerability of temocillin in Italian clinical practice. Methods: We retrospectively included adults treated with temocillin for UTIs, with or without concomitant bloodstream infection, for at least 5 days at three Italian hospitals between November 2024 and May 2026. Data were collected from electronic medical records. Results: The study included 30 patients. Median age was 51 years (IQR 39-74); 50% presented with sepsis and 40% had UTI-associated bacteraemia. Pyelonephritis was the most common presentation (53.3%). At least one positive culture was obtained in 76.7% of patients, yielding 28 isolates. Of these, 27 were Enterobacterales, and 21/27 (77.8%) were ESBL producers. E. coli accounted for 64.3% of all isolates. Temocillin was administered at 6 g/day in 80% of patients and by continuous infusion in 76.7%. Outpatient parenteral antimicrobial therapy (OPAT) using elastomeric pumps was used in 16.7% of patients. Clinical success at the end of the overall antimicrobial treatment course was achieved in 28/30 patients (93.3%; 95% CI 77.9-99.2%). No recurrence occurred within 30 days, and no treatment-related adverse events directly attributable to temocillin were recorded. Two patients developed Clostridioides difficile infection within 60 days after treatment completion, with no established causal relationship with temocillin. Conclusions: This first Italian multicentre real-world experience reports favourable clinical outcomes with temocillin in UTIs, including in selected patients with sepsis or UTI-associated bloodstream infection, and describes the use of continuous infusion and OPAT in appropriately selected patients.",
  "abstract_shown": true,
  "affiliations": [
    "Infectious Diseases Unit, University Hospital of Trieste (ASUGI), 34125 Trieste, Italy.",
    "Infectious Diseases Unit, Santa Chiara Hospital, Azienda Sanitaria Universitaria Integrata del Trentino (ASUIT), 38122 Trento, Italy.",
    "Centre for Medical Sciences (CISMed), University of Trento, 38122 Trento, Italy.",
    "Infectious Diseases Unit, Azienda Sanitaria Friuli Occidentale (ASFO), 33170 Pordenone, Italy.",
    "School of Medicine, University of Trieste, 34149 Trieste, Italy.",
    "Urology Unit, Santa Chiara Hospital, Azienda Sanitaria Universitaria Integrata del Trentino (ASUIT), 38122 Trento, Italy.",
    "Pharmacy Unit, Azienda Sanitaria Friuli Occidentale (ASFO), 33170 Pordenone, Italy.",
    "Pharmacy Unit, University Hospital of Trieste (ASUGI), 34125 Trieste, Italy.",
    "Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.",
    "Microbiology Unit, University Hospital of Trieste (ASUGI), 34149 Trieste, Italy.",
    "Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nicola Benvenuto",
      "orcid": "0009-0000-7663-9052"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Massimiliano Lanzafame",
      "orcid": "0000-0002-4674-4772"
    },
    {
      "affs": [
        3
      ],
      "name": "Sergio Venturini",
      "orcid": "0000-0003-0271-0826"
    },
    {
      "affs": [
        0
      ],
      "name": "Verena Zerbato",
      "orcid": "0000-0002-9204-032X"
    },
    {
      "affs": [
        4
      ],
      "name": "Arianna Perosa"
    },
    {
      "affs": [
        1
      ],
      "name": "Giovanni Mori",
      "orcid": "0000-0003-0399-2220"
    },
    {
      "affs": [
        3
      ],
      "name": "Giovanni Del Fabro"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Tommaso Cai",
      "orcid": "0000-0002-7234-3526"
    },
    {
      "affs": [
        6
      ],
      "name": "Chiara Zanusso"
    },
    {
      "affs": [
        7
      ],
      "name": "Filippo Giorgio Di Girolamo"
    },
    {
      "affs": [
        7
      ],
      "name": "Stefano Colla"
    },
    {
      "affs": [
        0
      ],
      "name": "Valentina Gerussi"
    },
    {
      "affs": [
        8
      ],
      "name": "Vasiliki Koumaki"
    },
    {
      "affs": [
        9
      ],
      "name": "Marina Busetti",
      "orcid": "0000-0002-8206-6841"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Stefano Di Bella",
      "orcid": "0000-0001-6121-7009"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/56rrvqh9mvw71.bib",
  "cited_by": 0,
  "doi": "10.3390/antibiotics15101034",
  "fulltext_url": "https://europepmc.org/articles/PMC13700802",
  "id": "56rrvqh9mvw71",
  "issns": [
    "2079-6382"
  ],
  "landing_url": "https://europepmc.org/article/MED/42938775",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Urinary Tract Infections Management"
    ]
  ],
  "openalex": "W7222923294",
  "pdf_url": "https://europepmc.org/articles/PMC13700802?pdf=render",
  "pmcid": "PMC13700802",
  "pmid": "42938775",
  "published": "2026-10-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/56rrvqh9mvw71.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42938775",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42938775"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Urinary Tract Infections Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Temocillin for the Treatment of Urinary Tract Infections: First Italian Data from a Multicentre Real-World Experience.",
  "title_text": "Temocillin for the Treatment of Urinary Tract Infections: First Italian Data from a Multicentre Real-World Experience.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/56rrvqh9mvw71",
  "venue": "Antibiotics (Basel, Switzerland)",
  "versions": []
}