{
  "abstract": "Langya virus is a zoonotic parahenipavirus with pandemic potential that causes acute febrile illness in people. We identified endothelial protein C receptor (EPCR) as an entry receptor for Langya, Wenzhou, and Mojiang parahenipaviruses. A 3.1 [A] cryo-electron microscopy structure reveals that Langya attachment glycoprotein engages EPCR through a site distinct from that of the ephrin binding site of Nipah G. This binding mode resembles those of protein C and a malarial adhesin, demonstrating convergent evolution. Interface substitutions abolish entry, whereas natural variation explains differential human EPCR use and predicts receptor compatibility across 26 animal species. These findings establish EPCR as a receptor for the Langya clade and provide a structural framework for understanding cross-species transmission and human infection potential.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Immunobiology, Yale University School of Medicine, New"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "name": "Z. Zhao"
    },
    {
      "name": "P. Tran"
    },
    {
      "name": "N. Li"
    },
    {
      "name": "L. Ou"
    },
    {
      "name": "J. Song"
    },
    {
      "name": "M. Sibilo"
    },
    {
      "name": "M. Castro"
    },
    {
      "name": "A. Chowdhury"
    },
    {
      "name": "J. A. Bohl"
    },
    {
      "name": "J. M. Wu"
    },
    {
      "name": "T. T. Do"
    },
    {
      "name": "B. Zhang"
    },
    {
      "name": "J. Zhao"
    },
    {
      "name": "A. C. Pal"
    },
    {
      "name": "C. W. Mullan"
    },
    {
      "name": "D. R. Martinez"
    },
    {
      "name": "R. W. Pierce"
    },
    {
      "name": "A. Spaulding"
    },
    {
      "name": "S. Lee"
    },
    {
      "name": "Y. Tsybovsky"
    },
    {
      "name": "L. Serebryannyy"
    },
    {
      "name": "D. C. Douek"
    },
    {
      "name": "T. Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "C. B. Wilen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/56y64374y2w3z.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.01.763137",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1.full",
  "id": "56y64374y2w3z",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/56y64374y2w3z.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T00:20:41Z",
      "native_id": "10.64898/2026.11.01.763137",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses",
  "title_text": "Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses",
  "type": "preprint",
  "updated_at": "2026-11-04T00:21:13Z",
  "url": "https://research.draconitic.com/paper/56y64374y2w3z",
  "venue": "bioRxiv",
  "versions": []
}