{
  "abstract": "Objective: Referral of older adults with thyroid nodular disease to surgery remains a challenge. We measured the impact of thyroid surgery on thyroid-related quality of life among older adults with nodular thyroid disease to aid decision-making.\n\nMethods: In this prospective study, all patients aged> 60 years undergoing thyroid surgery for nodular thyroid disease completed the short-form Thyroid-Related Quality of Life (QoL) Patient-Reported Outcome (ThyPRO-39), expanded to include the full 85-item ThyPRO scales for physical thyroid symptoms, at admission and 6–12 months after surgery. Thyroid function testing, histological reports, and surgery extension were recorded. Wilcoxon tests were corrected for multiple comparisons, and linear mixed models were employed in the statistical analyses.\n\nResults: Of 88 patients (81% female, age 71 ± 6 years), 31 had malignant and 57 benign nodules. After surgery, patients showed a significant improvement (p < 0.01) in 10 of the 13 ThyPRO scales, four physical symptoms, two mental well-being scales (Anxiety and emotional susceptibility), all QoL Impairment scales, and the ThyPRO-39 Composite scale (30 ± 17 vs. 21 ± 13, p < 0.01). Improvements in physical symptoms and QoL impairment scales were observed primarily in the benign nodules group ( p for interaction < 0.05). Although both lobectomy and total thyroidectomy improved QoL, lobectomized patients maintained T3 concentrations comparable to baseline.\n\nConclusion: Surgery improved most of the ThyPRO domains in older adults with nodular disease. Furthermore, goiter-related symptoms that impaired daily life and overall QoL improved primarily in benign disease. ThyPRO scores improved after both hemithyroidectomy and total thyroidectomy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Endocrinology and Metabolism, Unidad Asistencial Dr. César Milstein",
    "Department of Biochemistry, Unidad Asistencial Dr. César Milstein",
    "Department of Surgery, Unidad Asistencial Dr. César Milstein",
    "Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Nutrition and Food Safety Research Institute (INSA-UB), Faculty of Pharmacy and Food Sciences, University of Barcelona",
    "Medical and Translational Science, Novo Nordisk",
    "Department of Medicine, Zealand University Hospital",
    "Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital",
    "Institute of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vittorio Falco"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanina Morosán Allo"
    },
    {
      "affs": [
        0
      ],
      "name": "Carina Parisi"
    },
    {
      "affs": [
        0
      ],
      "name": "Cristina Faingold"
    },
    {
      "affs": [
        1
      ],
      "name": "Gabriel Fideleff"
    },
    {
      "affs": [
        2
      ],
      "name": "Maximiliano Lo Tartaro"
    },
    {
      "affs": [
        3
      ],
      "name": "Tomas Meroño"
    },
    {
      "affs": [
        4
      ],
      "name": "Torquil Watt"
    },
    {
      "affs": [
        5
      ],
      "name": "Victor Brun Boesen"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Ulla Feldt-Rassmussen"
    },
    {
      "affs": [
        0
      ],
      "name": "Gabriela Brenta"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/576pnnj4yzr9a.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1967551",
  "fulltext_url": "https://europepmc.org/articles/PMC13713259",
  "id": "576pnnj4yzr9a",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1967551/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2746|Thyroid and Parathyroid Surgery"
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  "openalex": "W7221805236",
  "pdf_url": "https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1967551/pdf",
  "pmcid": "PMC13713259",
  "pmid": "42952515",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/576pnnj4yzr9a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1967551",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1967551/full"
    },
    {
      "first_seen": "2026-10-31T00:20:34Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Thyroid and Parathyroid Surgery",
      "subfield": "surgery"
    }
  ],
  "title": "Assessment of changes in quality of life after thyroid surgery in older adults. A prospective study",
  "title_text": "Assessment of changes in quality of life after thyroid surgery in older adults. A prospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:57Z",
  "url": "https://research.draconitic.com/paper/576pnnj4yzr9a",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}