{
  "abstract": "Background\n\nPrevious studies on the association between statin use and the risk of Alzheimer's disease (AD) have yielded inconsistent results. This study, based on the large-scale UK Biobank cohort, evaluates the relationship between statin use and the risk of new-onset AD, survival in patients with AD, and cognitive function.Methods\n\nThis study included 502,401 participants with a median follow-up of 9.24 years. The association between statin use and the risk of AD was analyzed using Cox proportional hazards models, logistic regression, and propensity score matching. The robustness of the results was assessed through internal validation using training and validation groups, as well as subgroup analyses.Results\n\nA total of 975 new cases of AD were recorded. Multivariate Cox regression analysis showed that statin use was associated with a reduced risk of AD (HR = 0.72, 95% CI: 0.52-0.98; p < 0.05), and the results remained consistent after propensity score matching (p < 0.05). Among individuals aged ≥65 years, statin users demonstrated better cognitive performance than non-users. Concomitant use of antihypertensive or antidiabetic medications did not significantly alter the protective effect of statins.Conclusion\n\nStatin use was associated with a modestly lower risk of AD and slower cognitive decline. These findings highlight the importance of enhanced clinical awareness in identifying AD patients and those at risk of adverse outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Research Center, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.",
    "School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.",
    "School of Public Health Management, Hangzhou Normal University, Hangzhou, Zhejiang, China.",
    "Laboratory of Medicine, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.",
    "Zhejiang Key Laboratory of Zero Magnetic Medicine, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Hui Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Can Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jialu He"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yan Wei"
    },
    {
      "affs": [
        1
      ],
      "name": "Dongmei Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuan Luo"
    },
    {
      "affs": [
        0,
        3,
        4
      ],
      "name": "Ying Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/57t987cnqyv13.bib",
  "cited_by": 0,
  "doi": "10.3389/fnagi.2026.1961033",
  "fulltext_url": "https://europepmc.org/articles/PMC13680480",
  "id": "57t987cnqyv13",
  "issns": [
    "1663-4365"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903333",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7220692786",
  "pdf_url": "https://europepmc.org/articles/PMC13680480?pdf=render",
  "pmcid": "PMC13680480",
  "pmid": "42903333",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/57t987cnqyv13.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903333",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903333"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Association of statin use with reduced risk of Alzheimer's disease: findings in UK Biobank.",
  "title_text": "Association of statin use with reduced risk of Alzheimer's disease: findings in UK Biobank.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/57t987cnqyv13",
  "venue": "Frontiers in aging neuroscience",
  "versions": []
}