{
  "abstract": "Planar cell polarity (PCP) in epithelia is characterized by the polarized distribution of two opposing, membrane-associated PCP complexes across cell junctions. Transmembrane components of the PCP complex bridge cell junctions and organize into punctate, intercellular assemblies that exhibit a high degree of stability. Here, we define the contributions of the cytoplasmic PCP protein, Dishevelled (Dvl), in the sub-micron scale organization and stability of PCP complexes. Using endogenously-tagged fluorescent PCP reporters in the embryonic mouse epidermis, we quantify PCP protein mobility and clustering during polarization. We find that as transmembrane proteins immobilize into puncta, Dishevelled (Dvl2/3) co-accumulates with its transmembrane partner Frizzled (Fz6) in a polarized manner and stabilizes clusters of PCP complexes. We identify a previously unknown function for the oligomerizing DIX domain of Dvl3, typically associated with Wnt signaling, in Dvl3 asymmetric localization. These observations underscore a role for Dvl oligomerization in assembly and stabilization of asymmetric PCP puncta.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Parijat Sil",
      "orcid": "0000-0002-8391-8110"
    },
    {
      "affs": [
        0
      ],
      "name": "Brandon Trejo",
      "orcid": "0000-0003-4810-7897"
    },
    {
      "affs": [
        0
      ],
      "name": "Katherine A. Little",
      "orcid": "0000-0001-6993-5312"
    },
    {
      "affs": [
        0
      ],
      "name": "Danelle Devenport",
      "orcid": "0000-0002-5464-259X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/580ep67ktxdx0.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aeh6920",
  "fulltext_url": null,
  "id": "580ep67ktxdx0",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aeh6920",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Wnt/β-catenin signaling in development and cancer"
    ]
  ],
  "openalex": "W7221122232",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/580ep67ktxdx0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aeh6920",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aeh6920"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Wnt/β-catenin signaling in development and cancer",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Dishevelled-mediated clustering stabilizes Frizzled6 and Vangl2 to establish planar cell polarity in the mammalian skin",
  "title_text": "Dishevelled-mediated clustering stabilizes Frizzled6 and Vangl2 to establish planar cell polarity in the mammalian skin",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/580ep67ktxdx0",
  "venue": "Science Advances",
  "versions": []
}