{
  "abstract": "Introduction: Conventional Psoriasis Area and Severity Index (PASI) response rates provide a cross-sectional assessment of treatment effectiveness but do not capture the speed, magnitude, and persistence of clinical improvement. This study evaluated the patient-level cumulative clinical benefit of brodalumab over 52 weeks in routine clinical practice.\n\nMethods: This multicentre, retrospective, observational study included adults with moderate-to-severe plaque psoriasis treated with brodalumab within the Italian Landscape Psoriasis database. The primary analysis included patients with PASI assessments at baseline and Weeks 16, 32, and 52. Individual percentage PASI improvement trajectories were integrated using the trapezoidal area under the curve and expressed as normalized cumulative clinical benefit and clearance-equivalent days. Baseline factors associated with cumulative benefit were assessed using multivariable median quantile regression.\n\nResults: Among 858 patients eligible for the 52-week analysis, 764 had complete longitudinal PASI data, and 645 were included in the multivariable analysis. Median PASI decreased from 14.7 at baseline to 0.0 at Weeks 16, 32, and 52. At Week 52, 93.1%, 86.1%, and 70.4% of patients achieved PASI 75, PASI 90, and PASI 100, respectively. Median normalized cumulative clinical benefit was 97.4% (interquartile range, 90.0–100.0), corresponding to 300.0 clearance-equivalent days (277.2–308.0). Palmoplantar involvement was independently associated with lower cumulative benefit (adjusted median difference, − 3.21 percentage points; 95% confidence interval, − 6.29 to − 0.87), whereas scalp or facial involvement was associated with modestly higher benefit (+ 1.39; 0.38–3.27). Longer psoriasis duration was associated with a small increase in cumulative benefit.\n\nConclusion: Brodalumab provided rapid, deep, and sustained disease control over 52 weeks. Patient-level cumulative outcomes may complement conventional PASI response rates by capturing the overall longitudinal treatment benefit.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s13555-026-01925-5.",
  "abstract_shown": true,
  "affiliations": [
    "Departmental Faculty of Medicine UniCamillus-Saint Camillus International, University of Health and Medical Sciences, Rome, Italy",
    "Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy",
    "Department of Clinical Medicine, Internal Medicine Unit With Rheumatology, Dermatology, Diabetology and Tertiary Diabetic Foot Health-Care, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy",
    "Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties [PROMISE], University of Palermo, Palermo, Italy",
    "Department of Medical Science, Dermatology Clinic, University of Turin, Turin, Italy",
    "Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, Milan, Italy",
    "Department of Dermatology, Dipartimento di Scienze Della Salute (DISSal), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy",
    "Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy",
    "Dermatology Unit, University of Campania L. Vanvitelli, Naples, Italy",
    "Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan Italy",
    "Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy",
    "Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy",
    "Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy",
    "Department of Medical and Surgical Sciences Alma Mater, Studiorum University of Bologna, Bologna, Italy",
    "Dermatological Clinic, Department of Specialized Medicine, University of Modena, Modena, Italy",
    "Department of Clinical and Molecular Sciences-Dermatological Clinic, Università Politecnica Delle Marche, Ancona, Italy",
    "Dermatology Unit, Department of Clinical and Experimental Medicine, Ospedale Santa Chiara, Pisa, Italy",
    "Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy",
    "Dermatology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy",
    "Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy",
    "Unit of Dermatology, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy",
    "Dermatology Unit, Department of Medical and Cardiovascular Sciences, University of “La Sapienza”, Rome, Italy",
    "Institute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), Palermo, Italy",
    "Section of Dermatology, Italian Neurotraumatology Institute (I.N.I.), Grottaferrata, Italy",
    "Department of Biomedical, Dental Sciences and Morphofunctional Imaging (BIOMORF), University of Messina, Messina, Italy",
    "Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari “Aldo Moro”, Bari, Italy",
    "Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Milan, Italy",
    "U.O.S.D. Dermatologica-Centro per la Cura della Psoriasi, Ospedale Perrino, Brindisi, Italy"
  ],
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      "name": "Massimo Travaglini"
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  "bibtex": "https://research.draconitic.com/paper/58af1960ccntr.bib",
  "cited_by": 0,
  "doi": "10.1007/s13555-026-01925-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696622/",
  "id": "58af1960ccntr",
  "issns": [
    "2193-8210",
    "2190-9172"
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  "landing_url": "https://doi.org/10.1007/s13555-026-01925-5",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
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  "native_subjects": [
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      "Original Research"
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      "lcc",
      "RL1-803"
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      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
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  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s13555-026-01925-5.pdf",
  "pmcid": "PMC13696622",
  "pmid": "42754803",
  "published": "2026-09-01",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/58af1960ccntr.ris",
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  "subjects": [
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      "field": "biology",
      "origin": "openalex:2403|Psoriasis: Treatment and Pathogenesis",
      "subfield": "immunology"
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  ],
  "title": "Patient-Level Cumulative Clinical Benefit of Brodalumab Over 52 Weeks: A Multicentre Real-World Study-IL PSO (Italian Landscape Psoriasis)",
  "title_text": "Patient-Level Cumulative Clinical Benefit of Brodalumab Over 52 Weeks: A Multicentre Real-World Study-IL PSO (Italian Landscape Psoriasis)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:39Z",
  "url": "https://research.draconitic.com/paper/58af1960ccntr",
  "venue": "Dermatology and Therapy",
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