{
  "abstract": "Background: Pseudomyxoma peritonei (PMP) prognosis remains heterogeneous. Systemic inflammation and nutrition are linked to cancer survival, but their role in PMP is unclear. We aimed to evaluate the prognostic impact of inflammation–nutrition status in appendiceal high‐grade PMP and to develop and internally validate a perioperative prognostic model.\n\nMethods: We retrospectively included patients with pathologically confirmed appendiceal high‐grade PMP who underwent cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) between January 2015 and December 2024. Baseline variables included demographics, body mass index (BMI), tumor markers (CEA, CA19‐9, CA125), inflammation–nutrition indices (advanced lung cancer inflammation index [ALI], prognostic nutritional index [PNI], neutrophil‐to‐lymphocyte ratio [NLR], platelet‐to‐lymphocyte ratio [PLR], lymphocyte‐to‐monocyte ratio [LMR], systemic inflammation score [SIS], systemic immune–inflammation index [SII]), prior surgical score (PSS), peritoneal cancer index (PCI), completeness of cytoreduction (CC), HIPEC, pathological subtype, and Ki‐67. Overall survival (OS) was the primary endpoint. Prognostic factors were identified by univariable and multivariable Cox models, and a nomogram was developed and internally validated.\n\nResults: Among 223 patients (146 females, 65.5%), median age was 59 years, and median OS was 21 months. In the multivariable Cox regression model, independent risk factors for worse overall survival (OS) were high‐grade with signet‐ring cells (hazard ratio [HR] = 2.575, 95% CI 1.749–3.790; p < 0.001), elevated CA19‐9 (HR = 2.189, 95% CI 1.501–3.192; p < 0.001), elevated CA125 (HR = 1.495, 95% CI 1.050–2.127; p = 0.026), high Ki‐67 (HR = 1.976, 95% CI 1.238–3.154; p = 0.004), and an unfavorable CC (CC1–3) (HR = 2.705, 95% CI 1.295–5.648; p = 0.008), while receipt of hyperthermic intraperitoneal chemotherapy (HIPEC) (HR = 0.611, 95% CI 0.377–0.991; p = 0.046) and a high ALI (HR = 0.576, 95% CI 0.398–0.834; p = 0.003) were independent protective factors. The model achieved a C‐index of 0.753, with 1‐, 2‐, and 3‐year AUCs of 0.810, 0.839, and 0.775, respectively. Calibration error was low (≈3%–6%) and decision‐curve analysis showed sustained net benefit across broad threshold ranges.\n\nConclusions: The ALI is an independent prognostic marker in appendiceal high‐grade PMP. A nomogram incorporating ALI with tumor and pathological variables enabled reliable perioperative survival prediction with strong discrimination, calibration, and clinical utility.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology Beijing Chao‐Yang Hospital, Capital Medical University Beijing China",
    "Department of General Practice Aerospace Center Hospital Beijing China",
    "Department of Myxoma Aerospace Center Hospital Beijing China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yun Gao"
    },
    {
      "affs": [
        2
      ],
      "name": "Ruiqing Ma",
      "orcid": "0000-0003-2083-2800"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenhai Feng",
      "orcid": "0009-0008-2898-3412"
    },
    {
      "affs": [
        1
      ],
      "name": "Siyi Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Guangyu An"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/58cc71aecmen2.bib",
  "cited_by": 0,
  "doi": "10.1111/ans.70884",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724774/",
  "id": "58cc71aecmen2",
  "issns": [
    "1445-1433",
    "1445-2197"
  ],
  "landing_url": "https://doi.org/10.1111/ans.70884",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Surgical Oncology"
    ],
    [
      "openalex",
      "2746|Intraperitoneal and Appendiceal Malignancies"
    ]
  ],
  "openalex": "W7171298356",
  "pdf_url": null,
  "pmcid": "PMC13724774",
  "pmid": "42503461",
  "published": "2026-07-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/58cc71aecmen2.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:17Z",
      "native_id": "PMC13724774",
      "source": "pmc",
      "url": "https://doi.org/10.1111/ans.70884"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Intraperitoneal and Appendiceal Malignancies",
      "subfield": "surgery"
    }
  ],
  "title": "Advanced Lung Cancer Inflammation Index as a Prognostic Inflammation–Nutrition Marker in Appendiceal High‐Grade Pseudomyxoma Peritonei: A 10‐Year Single‐Center Study",
  "title_text": "Advanced Lung Cancer Inflammation Index as a Prognostic Inflammation–Nutrition Marker in Appendiceal High‐Grade Pseudomyxoma Peritonei: A 10‐Year Single‐Center Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:23:17Z",
  "url": "https://research.draconitic.com/paper/58cc71aecmen2",
  "venue": "Anz Journal of Surgery",
  "versions": []
}