{
  "abstract": "Introduction\n\nNodal T follicular helper cell lymphoma (nTFHL) with Epstein-Barr virus (EBV)-positive neoplastic T cells is rare.Methods\n\nWe report a woman with nTFHL and analyzed EBV-infected cells using an immunobead-based method and assessed somatic mutations in lymphoma and lymphoma-uninvolved bone marrow by targeted sequencing.Results\n\nEBV DNA was enriched in the CD4-positive fraction containing neoplastic T cells. Shared TET2 mutation was identified in both lymphoma and bone marrow, whereas additional TET2 and RHOA G17V mutations were restricted to the lymphoma.Conclusion\n\nThese findings support a stepwise model of EBV-positive nTFHL arising from TET2-mutated clonal hematopoiesis with subsequent acquisition of a RHOA mutation.Trial registration\n\nThe authors have confirmed clinical trial registration is not needed for this submission.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology Kobe City Medical Center General Hospital Kobe Japan.",
    "Department of Pathology Kobe City Medical Center General Hospital Kobe Japan.",
    "Department of Clinical Laboratory Kobe City Medical Center General Hospital Kobe Japan.",
    "Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan.",
    "Department of Virology Nagoya University Graduate School of Medicine Nagoya Japan.",
    "Department of Pathology and Tumor Biology Kyoto University Kyoto Japan.",
    "Division of Hematopoietic Disease Control Institute of Medical Science The University of Tokyo Tokyo Japan.",
    "Institute For the Advanced Study of Human Biology (WPI-ASHBi) Kyoto University Kyoto Japan."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Daichi Kishi",
      "orcid": "0009-0003-8702-0150"
    },
    {
      "affs": [
        0
      ],
      "name": "Nobuhiro Hiramoto",
      "orcid": "0000-0002-0472-6680"
    },
    {
      "affs": [
        1
      ],
      "name": "Daisuke Yamashita"
    },
    {
      "affs": [
        2
      ],
      "name": "Hayato Maruoka"
    },
    {
      "affs": [
        2
      ],
      "name": "Yumi Shiroishi"
    },
    {
      "affs": [
        0
      ],
      "name": "Masashi Nishikubo"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoshimitsu Shimomura"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryusuke Yamamoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuya Nagai"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuka Torii"
    },
    {
      "affs": [
        4
      ],
      "name": "Hiroshi Kimura"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Yasuhito Nannya"
    },
    {
      "affs": [
        5,
        7
      ],
      "name": "Seishi Ogawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Tadakazu Kondo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/58kmr6wkakds5.bib",
  "cited_by": 0,
  "doi": "10.1002/jha2.70449",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717066/?tool=EBI",
  "id": "58kmr6wkakds5",
  "issns": [
    "2688-6146"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717066",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Report"
    ],
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7224203693",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717066/pdf/?tool=EBI",
  "pmcid": "PMC13717066",
  "pmid": "42959303",
  "published": "2026-10-28",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/58kmr6wkakds5.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13717066",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717066"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42959303",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959303"
    },
    {
      "first_seen": "2026-11-02T12:21:27Z",
      "native_id": "PMC13717066",
      "source": "pmc",
      "url": "https://doi.org/10.1002/jha2.70449"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Nodal T Follicular Helper Cell Lymphoma With Epstein–Barr Virus‐Positive Neoplastic T Cells Derived From Clonal Hematopoiesis",
  "title_text": "Nodal T Follicular Helper Cell Lymphoma With Epstein–Barr Virus‐Positive Neoplastic T Cells Derived From Clonal Hematopoiesis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:27Z",
  "url": "https://research.draconitic.com/paper/58kmr6wkakds5",
  "venue": "EJHaem",
  "versions": []
}