{
  "abstract": "Aims\n\nTo examine index-window carcinoembryonic antigen (CEA), C-reactive protein (CRP), and five-year recorded mortality by ethnicity in colorectal cancer.Patients and methods\n\nThis retrospective University of California Health Data Warehouse cohort included Hispanic/Latino and non-Hispanic White adults indexed during 2012-2020 with both biomarkers measured within ±30 days and complete covariates. Linear regression modeled log(CEA + 0.1); Cox regression modeled recorded all-cause mortality.Results\n\nAmong 345 patients, 143 deaths were recorded. Hispanic/Latino ethnicity was associated with higher log(CEA + 0.1) (β = 0.743; robust 95% confidence interval [CI], 0.202-1.285; P = 0.007). The mortality association was nonsignificant (hazard ratio [HR], 0.723; 95% CI, 0.483-1.084; P = 0.117). Higher log(CEA + 0.1) (HR, 1.266; 95% CI, 1.174-1.366; P < 0.001) and log(CRP + 0.1) (HR, 1.134; 95% CI, 1.037-1.239; P = 0.006) were associated with mortality.Conclusions\n\nIn this biomarker-selected cohort, Hispanic/Latino patients had higher recorded CEA without a statistically significant ethnic-group mortality difference. Confirmation requires clinically characterized cohorts with stage, treatment, biomarker timing, verified assay comparability, and complete mortality ascertainment.",
  "abstract_shown": true,
  "affiliations": [
    "University of California San Diego School of Medicine, San Diego, CA, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Freddy Martinez"
    },
    {
      "affs": [
        0
      ],
      "name": "Raphael E Cuomo",
      "orcid": "0000-0002-8179-0619"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/58npfhndxqykv.bib",
  "cited_by": 0,
  "doi": "10.1080/20565623.2026.2743711",
  "fulltext_url": "https://europepmc.org/articles/PMC13652077",
  "id": "58npfhndxqykv",
  "issns": [
    "2056-5623"
  ],
  "landing_url": "https://europepmc.org/article/MED/42848519",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7220921188",
  "pdf_url": "https://europepmc.org/articles/PMC13652077?pdf=render",
  "pmcid": "PMC13652077",
  "pmid": "42848519",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/58npfhndxqykv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42848519",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42848519"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Index-window C-reactive protein and carcinoembryonic antigen and five-year all-cause mortality in Hispanic/Latino and non-Hispanic White patients with colorectal cancer: a retrospective biomarker cohort study.",
  "title_text": "Index-window C-reactive protein and carcinoembryonic antigen and five-year all-cause mortality in Hispanic/Latino and non-Hispanic White patients with colorectal cancer: a retrospective biomarker cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/58npfhndxqykv",
  "venue": "Future science OA",
  "versions": []
}