{
  "abstract": "In the search for potent bioactive compounds derived from medicinal plants, Garcinia parvifolia from East Kalimantan has demonstrated significant bioactivity consistent with established scientific criteria. Bioassay-guided isolation of the fruit extract resulted in two new depsidones named methyl garcidepsidone B (1) and parvifoliricodone A (6), two known analogues, a phloroglucinol, and a furfural derivative. Their structures were determined by spectroscopic techniques. The isolated compounds were subjected to assessments for their potential antidiabetic effects through an α-glucosidase inhibition assay, anti-tyrosinase activity, and antioxidant properties. Out of the isolated compounds, methyl garcidepsidone B (1) was the most potent inhibitor against α-glucosidase compared with acarbose as a positive standard. In the antioxidant assay, all isolated compounds showed significant free radical scavenging activity against ABTS, with the exception of compound 4. Regarding tyrosinase inhibitory activity, all isolated compounds exhibited low enzyme inhibition activity. Additionally, in silico molecular docking studies showed that compounds 1-3 exhibited favorable conformation and binding affinities within the enzymatic pockets of α-glucosidase. These findings indicate that the indigenous G. parvifolia fruit may serve as a natural source of antidiabetic, antioxidant, and anti-tyrosinase compounds, with potential for further pharmacological investigation.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Exploration and Synthesis of Bioactive Compounds (ESBC), University CoE - Research Center for Bio-Molecule Engineering (BIOME), Universitas Airlangga Surabaya 60115 Indonesia.",
    "Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga Surabaya 60115 Indonesia rico.ramadhan@fst.unair.ac.id.",
    "Plant Biomass Utilization Research Unit, Department of Botany, Faculty of Science, Chulalongkorn University Bangkok 10330 Thailand.",
    "Department of Chemistry, Faculty of Science, Universiti Malaya Kuala Lumpur 50603 Malaysia.",
    "Faculty of Pharmacy, Ton Duc Thang University Ho Chi Minh City Vietnam.",
    "Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University Bangkok 10330 Thailand.",
    "Program in Bioinformatics and Computational Biology, College of Interdisciplinary and Integrative Studies, Chulalongkorn University Bangkok 10330 Thailand.",
    "Center of Excellent in Natural Products (CENP), Department of Chemistry, Faculty of Science, Chulalongkorn University Bangkok 10330 Thailand.",
    "Department of Chemistry, Faculty of Science and Technology, Thammasat University Lampang Campus Lampang 52190 Thailand.",
    "Environmental Office of Balikpapan Balikpapan 76115 East Kalimantan Indonesia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Rico Ramadhan",
      "orcid": "0000-0002-2565-7944"
    },
    {
      "affs": [
        3
      ],
      "name": "Azeana Zahari",
      "orcid": "0000-0002-5279-0169"
    },
    {
      "affs": [
        1
      ],
      "name": "Irmayanti Tri Kurnia"
    },
    {
      "affs": [
        4
      ],
      "name": "Anh-Khoa Nguyen"
    },
    {
      "affs": [
        2
      ],
      "name": "Sehanat Prasongsuk"
    },
    {
      "affs": [
        5
      ],
      "name": "Yazdaniyar Fajri Halimi Firdaus"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Thanyada Rungrotmongkol"
    },
    {
      "affs": [
        7
      ],
      "name": "Preecha Phuwapraisirisan"
    },
    {
      "affs": [
        0
      ],
      "name": "Dinda Ayu Lestari"
    },
    {
      "affs": [
        8
      ],
      "name": "Jirapast Sichaem"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kautsar Ul-Haq",
      "orcid": "0000-0002-0584-5040"
    },
    {
      "affs": [
        1
      ],
      "name": "Aziz Ahmad Bukhori"
    },
    {
      "affs": [
        1
      ],
      "name": "Devi Nawang Ariningtyas"
    },
    {
      "affs": [
        9
      ],
      "name": "Lukman Riyadi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/58qew833emxsd.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06497c",
  "fulltext_url": "https://europepmc.org/articles/PMC13688104",
  "id": "58qew833emxsd",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923738",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1110|Natural Compound Pharmacology Studies"
    ]
  ],
  "openalex": "W7223188034",
  "pdf_url": "https://europepmc.org/articles/PMC13688104?pdf=render",
  "pmcid": "PMC13688104",
  "pmid": "42923738",
  "published": "2026-10-22",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/58qew833emxsd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923738",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923738"
    },
    {
      "first_seen": "2026-11-07T12:23:37Z",
      "native_id": "PMC13688104",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra06497c"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Natural Compound Pharmacology Studies",
      "subfield": "plant-biology"
    }
  ],
  "title": "New depsidones from Garcinia parvifolia and their antidiabetic, anti-tyrosinase, and antioxidant activities.",
  "title_text": "New depsidones from Garcinia parvifolia and their antidiabetic, anti-tyrosinase, and antioxidant activities.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:37Z",
  "url": "https://research.draconitic.com/paper/58qew833emxsd",
  "venue": "RSC advances",
  "versions": []
}