{
  "abstract": "Background: A rare and serious adverse outcome of sepsis is surgical amputation. Limited research has examined the prevalence and risk factors associated with amputations among sepsis patients.\n\nAims: To (i) assess the rate of sepsis‐related amputations in hospitals and (ii) identify associated risk factors.\n\nMethods: A retrospective cohort study of sepsis patients admitted to any hospital in New South Wales, Australia, from 1 January 2015, to 31 January 2021. The primary outcome was the rate of amputations in sepsis patients. The secondary outcome was amputation risk factors, identified using multivariable logistic regression.\n\nResults: There were 158 842 sepsis patients hospitalised during the study period. The amputation rate was 1.11% (1637/148061) in non‐maternal adult patients, 0% (0/3656) in maternal sepsis patients, and < 0.15% (< 10/7125) in paediatric patients. In adult patients with septic shock (n = 20 354), 283 (1.39%) had an amputation. After adjustment for sex, age group, socioeconomic status, geographical remoteness, diabetes and peripheral arterial disease (PAD), factors associated with a higher odds of amputation in adult patients (n = 148 061) were being male (adjusted Odds Ratio [aOR] 2.16, 95% CI: 1.93–2.43; p < 0.001), having diabetes (aOR 9.06, 95% CI: 8.01–10.23; p < 0.001) or having PAD (aOR 19.29, 95% CI: 17.01–21.88; p < 0.001). Compared to patients aged ≥ 85 years, those 16 to 59 years (aOR 3.65, 95% CI: 3.00–4.44; p < 0.001) and 60 to 84 years (aOR 2.19, 95% CI: 1.83–2.63; p < 0.001) also had higher odds of amputation.\n\nConclusions: This large population study provides much‐needed evidence on the burden and risk factors of amputations in sepsis patients.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Macquarie University Sydney Australia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Khalia Ackermann",
      "orcid": "0000-0001-9868-9456"
    },
    {
      "affs": [
        0
      ],
      "name": "Nanda Aryal",
      "orcid": "0000-0003-3118-2006"
    },
    {
      "affs": [
        0
      ],
      "name": "Johanna Westbrook",
      "orcid": "0000-0003-1083-8192"
    },
    {
      "affs": [
        0
      ],
      "name": "Ling Li",
      "orcid": "0000-0002-1642-142X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/598y040v65jf7.bib",
  "cited_by": 0,
  "doi": "10.1111/ans.70835",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724777/",
  "id": "598y040v65jf7",
  "issns": [
    "1445-1433",
    "1445-2197"
  ],
  "landing_url": "https://doi.org/10.1111/ans.70835",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "General Surgery"
    ],
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7166864215",
  "pdf_url": null,
  "pmcid": "PMC13724777",
  "pmid": "42386515",
  "published": "2026-07-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/598y040v65jf7.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:17Z",
      "native_id": "PMC13724777",
      "source": "pmc",
      "url": "https://doi.org/10.1111/ans.70835"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Amputations in Sepsis Patients: A Population‐Based Cohort Study of Rates and Risk Factors",
  "title_text": "Amputations in Sepsis Patients: A Population‐Based Cohort Study of Rates and Risk Factors",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:10Z",
  "url": "https://research.draconitic.com/paper/598y040v65jf7",
  "venue": "Anz Journal of Surgery",
  "versions": []
}