{
  "abstract": "Early unplanned readmissions after radiotherapy-based treatment may reflect residual toxicity and gaps in supportive care coordination. We examined associations between predischarge hematological and albumin marker patterns and 30-day hematological toxicity-related unplanned readmission in nasopharyngeal carcinoma (NPC). This multicenter retrospective cohort study included 607 patients discharged after hospitalization involving radiotherapy-based treatment at three tertiary hospitals in southwestern China between December 2018 and March 2026. The primary complete-case sample comprised 588 patients with predischarge absolute neutrophil count (ANC), platelet count (PLT), and albumin measurements. Core markers were ANC <1.5 × 10⁹/L, PLT <200 × 10⁹/L, and albumin <35 g/L. We used association rule mining and Firth penalized logistic regression. Chemotherapy and supportive care variables were examined in sensitivity analyses, and all-cause 30-day unplanned readmission was a supportive secondary outcome. Based on the chronologically first readmission within 30 days, 77 of 607 patients (12.7%) were classified as having an unplanned readmission; 58 of the 77 (75.3%) were classified as hematological toxicity-related. In the primary sample, hematological readmission rates were 4.9%, 13.1%, and 17.5% for zero, one, and two or more core markers, respectively. Adjusted odds ratios (ORs) were 2.86 [95% confidence interval (CI) 1.50-5.46] and 4.33 (95% CI 1.82-10.30) for one and two or more markers versus zero markers. Corresponding ORs were 2.93 and 4.55 after chemotherapy adjustment and 2.59 and 3.47 after supportive care adjustment. The all-cause analysis showed a similar gradient (OR 2.65, 95% CI 1.52-4.61; OR 3.18, 95% CI 1.43-7.05). Routine predischarge measures were associated with early readmission risk, but the findings do not establish causality or a clinical decision rule. Prospective external validation is required before clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "School of Nursing, Youjiang Medical University for Nationalities, Baise, Guangxi, China.",
    "Department of Oncology, People's Hospital of Qianxinan Prefecture, Guizhou Province, China.",
    "Faculty of Medicine, Imperial College London, London, United Kingdom.",
    "Cardiac Intensive Care Unit, Department of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Guifei Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Qianxi Sha"
    },
    {
      "affs": [
        0
      ],
      "name": "Lihong Zhao"
    },
    {
      "affs": [
        2
      ],
      "name": "Suren Rao Sooranna"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Huiying Tan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/59bhkrstkmbp9.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1929774",
  "fulltext_url": "https://europepmc.org/articles/PMC13713644",
  "id": "59bhkrstkmbp9",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952952",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7221770823",
  "pdf_url": "https://europepmc.org/articles/PMC13713644?pdf=render",
  "pmcid": "PMC13713644",
  "pmid": "42952952",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/59bhkrstkmbp9.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42952952",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952952"
    },
    {
      "first_seen": "2026-10-31T12:24:09Z",
      "native_id": "PMC13713644",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1929774"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "Predischarge blood count and nutritional risk marker patterns associated with 30-day unplanned readmissions for hematological toxicity after radiotherapy for nasopharyngeal carcinoma: a multicenter cohort study.",
  "title_text": "Predischarge blood count and nutritional risk marker patterns associated with 30-day unplanned readmissions for hematological toxicity after radiotherapy for nasopharyngeal carcinoma: a multicenter cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:17Z",
  "url": "https://research.draconitic.com/paper/59bhkrstkmbp9",
  "venue": "Frontiers in medicine",
  "versions": []
}