{
  "abstract": "Background\n\nDyslipidaemia is a major risk factor for cardiovascular and cerebrovascular diseases; however, the optimal frequency of medical visits remains unclear.Objective\n\nTo examine whether medical visit frequency is associated with the incidence of cardiac events, cerebrovascular events, and mortality among patients initiating lipid-lowering therapy.Methods\n\nWe conducted a retrospective cohort study using data from the Shizuoka Kokuho Database between April 1, 2012, and September 30, 2021. Patients initiating lipid-lowering therapy were classified into high-frequency (≥ 22 visits in 2 years) and low-frequency (8-12 visits in 2 years) groups. After 1:3 propensity score matching and exclusion of patients with events within 2 years, 1,435 patients in the low-frequency group and 4,412 in the high-frequency group were analysed.Results\n\nOver a mean follow-up of 5.3 years, composite outcomes occurred in 5.6% of both groups (hazard ratio [HR] 1.08; 95% confidence interval [CI] 0.84-1.38; p = 0.571). No significant differences were observed for cardiac events (HR 1.13; 95% CI 0.83-1.54), cerebrovascular events (HR 1.13; 95% CI 0.67-1.90), or mortality (HR 0.94; 95% CI 0.60-1.48).Conclusion\n\nLess frequent visits were not associated with increased risks of cardiovascular events or mortality. Extending visit intervals may therefore be a reasonable option for selected stable patients receiving lipid-lowering therapy for primary prevention.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate School of Public Health, Shizuoka Graduate University of Public Health, 4-27-2 Kitaando, Aoi-ku, Shizuoka, 420-0881, Japan.",
    "Department of General Medicine, Fujieda Municipal General Hospital, Shizuoka, Japan.",
    "Graduate School of Public Health, Shizuoka Graduate University of Public Health, 4-27-2 Kitaando, Aoi-ku, Shizuoka, 420-0881, Japan. nakatani.eiji.int@gmail.com.",
    "Laboratory of Biostatistics, NHO Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, 460-0001, Japan. nakatani.eiji.int@gmail.com.",
    "Center for Health Informatics Policy, National Institute of Public Health, Saitama, Japan.",
    "Okinaka Memorial Institute for Medical Research, Tokyo, Japan.",
    "Allied Medical K.K, Tokyo, Japan.",
    "Graduate School of Public Health, Shizuoka Graduate University of Public Health, 4-27-2 Kitaando, Aoi-ku, Shizuoka, 420-0881, Japan. asugawara@s-sph.ac.jp."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Taku Matsunaga"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Eiji Nakatani",
      "orcid": "0000-0002-4876-446X"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Yasuto Sato"
    },
    {
      "affs": [
        5
      ],
      "name": "Hideaki Kaneda"
    },
    {
      "affs": [
        6
      ],
      "name": "Hiromitsu Ohno"
    },
    {
      "affs": [
        7
      ],
      "name": "Akira Sugawara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/59fj5hqpmew4q.bib",
  "cited_by": 0,
  "doi": "10.1186/s41043-026-01408-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13721620",
  "id": "59fj5hqpmew4q",
  "issns": [
    "1606-0997",
    "2072-1315"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958461",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7172170550",
  "pdf_url": "https://europepmc.org/articles/PMC13721620?pdf=render",
  "pmcid": "PMC13721620",
  "pmid": "42958461",
  "published": "2026-08-02",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/59fj5hqpmew4q.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958461",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958461"
    },
    {
      "first_seen": "2026-11-03T12:22:17Z",
      "native_id": "PMC13721620",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s41043-026-01408-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Association of medical visit frequency with cardiovascular events and mortality in patients with dyslipidaemia: a cohort study using a Japanese claims database.",
  "title_text": "Association of medical visit frequency with cardiovascular events and mortality in patients with dyslipidaemia: a cohort study using a Japanese claims database.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:17Z",
  "url": "https://research.draconitic.com/paper/59fj5hqpmew4q",
  "venue": "Journal of health, population, and nutrition",
  "versions": []
}