{
  "abstract": "目的: 明确4F-ABUTINACA的Δ9-四氢大麻酚（THC）样辨别刺激效应，并探讨4F-ABUTINACA慢性给药诱发类焦虑行为的潜在作用机制。\n\n方法: 取6只成年Sprague-Dawley雄性大鼠，通过药物辨别实验测定4F-ABUTINACA的THC样辨别刺激效应，并观察大麻素受体1（CB1受体）拮抗剂利莫那班对其辨别刺激效应的影响。另取48只大鼠适应性饲养5 d，随机分为溶剂对照组、4F-ABUTINACA小剂量组（0.3 mg/kg）和大剂量组（2.0 mg/kg），每组16只。连续腹腔注射溶剂或4F-ABUTINACA 15 d，分别在第21天（短期）或第40天（长期）通过旷场实验和高架十字迷宫实验评估大鼠类焦虑行为；通过免疫荧光法观察海马胶质细胞激活情况及抑制性突触标志物的表达变化；采用蛋白质印迹法检测海马突触可塑性相关蛋白质表达。\n\n结果: 大鼠形成稳定的THC（2.0 mg/kg）辨别反应，4F-ABUTINACA（2.0 mg/kg）能完全替代THC，且该辨别刺激效应可被利莫那班部分抑制。停药后短期，4F-ABUTINACA小剂量组在旷场实验中表现出类焦虑行为，大剂量组在旷场实验和高架十字迷宫实验中均出现类焦虑行为；停药后长期仅4F-ABUTINACA大剂量组在高架十字迷宫实验中表现出类焦虑行为。停药后短期4F-ABUTINACA小剂量和大剂量暴露均可引起海马神经炎症反应［离子钙结合适配分子1（IBA-1）阳性细胞数及胶质纤维酸性蛋白（GFAP）表达增加］、突触受体表达改变［N-甲基-D-天冬氨酸受体（NMDAR）2A、NMDAR2B水平降低，离子型谷氨酸受体AMPA亚型1（GluA1）水平升高，小剂量组突触小体相关蛋白25（SNAP25）水平亦降低］及抑制性突触损伤［桥尾蛋白水平降低，大剂量组囊泡γ氨基丁酸转运体（VGAT）水平亦降低］，且大剂量组部分改变更为显著；停药后长期4F-ABUTINACA小剂量组的神经炎症指标基本恢复，而大剂量组神经炎症反应持续存在（IBA-1阳性细胞数及GFAP表达仍增多），并伴有更广泛的突触损伤（NMDAR2A、NMDAR2B及SNAP25水平降低）和抑制性突触损伤。\n\n结论: 4F-ABUTINACA能通过激活CB1受体产生THC样辨别刺激效应，其慢性给药致大鼠产生类焦虑行为机制可能与海马小胶质细胞和星形胶质细胞标志物持续高表达及突触可塑性损伤有关。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "宝宝 史",
      "orcid": "0009-0005-6750-7222"
    },
    {
      "name": "海涛 王"
    },
    {
      "name": "文华 周"
    },
    {
      "name": "苗军 赖",
      "orcid": "0009-0002-8362-3803"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5a0qhdyj6sxk4.bib",
  "cited_by": 0,
  "doi": "10.3724/zdxbyxb-2025-0891",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722845/",
  "id": "5a0qhdyj6sxk4",
  "issns": [
    "1008-9292"
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  "landing_url": "https://doi.org/10.3724/zdxbyxb-2025-0891",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Monographic Reports"
    ],
    [
      "heading",
      "R749"
    ],
    [
      "heading",
      "a"
    ],
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      "openalex",
      "2736|Cannabis and Cannabinoid Research"
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  "openalex": "W7213956627",
  "pdf_url": null,
  "pmcid": "PMC13722845",
  "pmid": "42767823",
  "published": "2026-09-25",
  "publisher": "Zhejiang University Press",
  "ris": "https://research.draconitic.com/paper/5a0qhdyj6sxk4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:35Z",
      "native_id": "PMC13722845",
      "source": "pmc",
      "url": "https://doi.org/10.3724/zdxbyxb-2025-0891"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Cannabis and Cannabinoid Research",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "合成大麻素4F-ABUTINACA慢性给药致大鼠类焦虑行为及其作用机制",
  "title_text": "合成大麻素4F-ABUTINACA慢性给药致大鼠类焦虑行为及其作用机制",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:35Z",
  "url": "https://research.draconitic.com/paper/5a0qhdyj6sxk4",
  "venue": "Journal of Zhejiang University (Medical Sciences)",
  "versions": []
}