{
  "abstract": "Four previously undescribed Euphane triterpenes, comprising three dynamic epimerization pairs (1-3) and a tetranor derivative (5), as well as eight known analogues (4 and 6-12), have been separated from the tubers of Euphorbia antiquorum. Their structures were characterized by spectroscopic methods, including HR-ESIMS, NMR and ECD. All of them were evaluated for their inhibitory activity against the diabetic target α-glucosidase. Compound 5 exhibited the most potent activity with an IC₅₀ value of 13.6 µM. The binding mode of 5 to α-glucosidase was further investigated, which identified it as a mixed-type inhibitor.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry and Chemical Engineering, University of Jinan, Jinan, China.",
    "School of Biological Science and Technology, University of Jinan, Jinan, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ren-Fen Ma",
      "orcid": "0009-0000-6647-6886"
    },
    {
      "affs": [
        1
      ],
      "name": "Chen-Yu Wang",
      "orcid": "0009-0005-8668-3782"
    },
    {
      "affs": [
        1
      ],
      "name": "Kai-Yue Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Hua Zhang",
      "orcid": "0000-0002-5959-6473"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5a5k9yts45z2w.bib",
  "cited_by": 0,
  "doi": "10.1002/cbdv.71823",
  "fulltext_url": "https://europepmc.org/articles/PMC13684310",
  "id": "5a5k9yts45z2w",
  "issns": [
    "1612-1872",
    "1612-1880"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902916",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Bioactive Natural Diterpenoids Research"
    ]
  ],
  "openalex": "W7223139980",
  "pdf_url": "https://europepmc.org/articles/PMC13684310?pdf=render",
  "pmcid": "PMC13684310",
  "pmid": "42902916",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5a5k9yts45z2w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42902916",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902916"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bioactive Natural Diterpenoids Research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Triterpenes with α-Glucosidase Inhibitory Activity from Euphorbia antiquorum.",
  "title_text": "Triterpenes with α-Glucosidase Inhibitory Activity from Euphorbia antiquorum.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/5a5k9yts45z2w",
  "venue": "Chemistry & biodiversity",
  "versions": []
}