{
  "abstract": "The stochastic nature of DNA damage dictates various scenarios of stress survival among different cells. We used time-lapse microscopy to perform single-cell level analyses of yeast populations with double-stranded DNA breaks and nonfunctional telomeres. Activation of the DNA damage signalling resulted in a broad distribution in the duration of G2/M arrests. Strikingly, the longer arrests correlated with aberrant mitoses caused by miscoordination of nuclear division and cytokinesis, leading to cell death. Chk1-dependent phosphorylation of Pds1 (securin), an inhibitor of sister chromatid separation in mitosis, was responsible for this phenomenon. Securin progressively accumulated during G2/M arrests, leading to grossly delayed or missed nuclear divisions. This phenotype could be suppressed by slowing down the progression of mitotic exit via LTE1 deletion or by lowering securin levels. Our results demonstrate that in cells taking too long to complete DNA repair, the DNA damage checkpoint promotes aberrant mitoses and cell death, thereby eliminating cells with a higher chance of genomic instability.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Cell Biology, University of Edinburgh , Edinburgh, UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anton Dubenko",
      "orcid": "0009-0009-5752-2938"
    },
    {
      "affs": [
        0
      ],
      "name": "Marah Jnied",
      "orcid": "0000-0002-8486-0563"
    },
    {
      "affs": [
        0
      ],
      "name": "Oleksii Kotenko",
      "orcid": "0009-0003-9098-0179"
    },
    {
      "affs": [
        0
      ],
      "name": "Svetlana Makovets",
      "orcid": "0000-0002-0226-2093"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5aas8hfqszs9w.bib",
  "cited_by": 0,
  "doi": "10.1083/jcb.202511106",
  "fulltext_url": "https://europepmc.org/articles/PMC13726689",
  "id": "5aas8hfqszs9w",
  "issns": [
    "0021-9525",
    "1540-8140"
  ],
  "landing_url": "https://europepmc.org/article/MED/42969970",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Cell Cycle and Division"
    ],
    [
      "heading",
      "Genetics"
    ],
    [
      "openalex",
      "1312|DNA Repair Mechanisms"
    ]
  ],
  "openalex": "W4412538448",
  "pdf_url": "https://europepmc.org/articles/PMC13726689?pdf=render",
  "pmcid": "PMC13726689",
  "pmid": "42969970",
  "published": "2026-11-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5aas8hfqszs9w.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42969970",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42969970"
    },
    {
      "first_seen": "2026-11-05T12:22:58Z",
      "native_id": "PMC13726689",
      "source": "pmc",
      "url": "https://doi.org/10.1083/jcb.202511106"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Genetics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Extended DNA damage-induced G2/M arrests lead to aberrant mitoses through accumulation of securin.",
  "title_text": "Extended DNA damage-induced G2/M arrests lead to aberrant mitoses through accumulation of securin.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:34Z",
  "url": "https://research.draconitic.com/paper/5aas8hfqszs9w",
  "venue": "The Journal of cell biology",
  "versions": []
}