{
  "abstract": "Background/Objectives: Comparative data on metastasis-directed therapy (MDT) versus systemic therapy in oligometastatic endometrial carcinoma (EC) recurrence are lacking. Methods: In this retrospective population-based registry study (Tumor Register Saxony-Anhalt, 2000–2025), we included 153 treated patients with distant-only oligometastatic EC recurrence (≤2 anatomical sites) after curative-intent primary treatment. Overall survival (OS) was compared between a strategy including MDT (n = 97) and systemic therapy alone (n = 56) using inverse probability of treatment weighting (IPTW)-adjusted Cox regression. Subgroup, sensitivity and competing risks analyses were exploratory. Results: In the IPTW analysis (n = 145 with complete data), OS did not differ significantly between MDT and systemic therapy (hazard ratio [HR] 0.90, 95% confidence interval [CI] 0.61–1.35; p = 0.622), consistent across sensitivity analyses. In exploratory subgroup analysis, MDT was associated with better OS in high-grade tumors (n = 51; HR 0.27, 95% CI 0.12–0.59; p = 0.001; Holm-adjusted p = 0.013), but not in low-grade tumors (HR 1.29; p = 0.339). Conclusions: MDT and systemic therapy showed no statistically significant survival difference in unselected oligometastatic EC recurrence; the confidence interval cannot exclude clinically relevant benefit or harm, supporting individualized decisions. The high-grade finding is hypothesis-generating and warrants prospective validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Paolo Gennari",
      "orcid": "0009-0005-5286-7735"
    },
    {
      "affs": [
        0
      ],
      "name": "Mandy Busse"
    },
    {
      "affs": [
        0
      ],
      "name": "Atanas Ignatov"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5ab4keevtn63q.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18203382",
  "fulltext_url": null,
  "id": "5ab4keevtn63q",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/20/3382",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7222919144",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-19",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/5ab4keevtn63q.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18203382",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/20/3382"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Metastasis-Directed Therapy Versus Systemic Therapy in Oligometastatic Endometrial Carcinoma Recurrence: A Population-Based Registry Analysis",
  "title_text": "Metastasis-Directed Therapy Versus Systemic Therapy in Oligometastatic Endometrial Carcinoma Recurrence: A Population-Based Registry Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:58Z",
  "url": "https://research.draconitic.com/paper/5ab4keevtn63q",
  "venue": "Cancers",
  "versions": []
}