{
  "abstract": "Parahydrogen-induced polarization (PHIP) represents a cost-effective hyperpolarization technique providing dramatic increase of the NMR spectroscopy sensitivity. In particular, hyperpolarized metabolites are employed in various in vivo applications, including cancer diagnostics and grading. In this proof-of-concept study, we present an extension of the PHIP methodology to a key nitrogenous metabolite, the nitrate anion. We report an approach for the production of hyperpolarized nitrate solutions utilizing PHIP by means of the side-arm hydrogenation of propargyl nitrate ester. Through the sequential optimization of hydrogenation, polarization transfer, and hydrolysis procedures, we obtained hyperpolarized nitrate anion with 15 N polarization levels estimated as >2%.",
  "abstract_shown": true,
  "affiliations": [
    "International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk, Russia, 630090",
    "Novosibirsk State University, 2 Pirogova St., Novosibirsk, Russia, 630090",
    "Smart Materials Research Institute, 178/24 Sladkova St., Rostov-on-Don, Russia, 344090"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Nazim R. Mustafin",
      "orcid": "0009-0001-6552-0248"
    },
    {
      "affs": [
        0
      ],
      "name": "Dudari B. Burueva",
      "orcid": "0000-0002-6077-5487"
    },
    {
      "affs": [
        0
      ],
      "name": "Sergey V. Sviyazov",
      "orcid": "0000-0002-8555-8403"
    },
    {
      "affs": [
        0
      ],
      "name": "Nikita V. Chukanov",
      "orcid": "0000-0003-1246-8869"
    },
    {
      "affs": [
        2
      ],
      "name": "Alexander A. Guda",
      "orcid": "0000-0002-6941-4987"
    },
    {
      "affs": [
        0
      ],
      "name": "Oleg G. Salnikov"
    },
    {
      "affs": [
        0
      ],
      "name": "Igor V. Koptyug",
      "orcid": "0000-0003-3480-7649"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5anzceba3ww4t.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009584/v1",
  "fulltext_url": null,
  "id": "5anzceba3ww4t",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009584/v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1607|Advanced NMR Techniques and Applications"
    ]
  ],
  "openalex": "W7214760639",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009584/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-28",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/5anzceba3ww4t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009584",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009584/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Advanced NMR Techniques and Applications",
      "subfield": "physical"
    }
  ],
  "title": "Parahydrogen-induced 15N polarization of nitrate ion",
  "title_text": "Parahydrogen-induced 15N polarization of nitrate ion",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/5anzceba3ww4t",
  "venue": "ChemRxiv",
  "versions": []
}