{
  "abstract": "A novel Ru‐catalyzed asymmetric transfer hydrogenation (ATH) strategy has been developed for the efficient synthesis of valuable chiral α ‐aminophosphonates from readily available α ‐iminophosphonates. This method enables the conversion of both acyclic and cyclic substrates in high yields (up to 97%) and excellent enantioselectivities (up to >99:1), providing a practical entry to phosphorus‐containing chiral amines. Notably, this is the first reported application of ATH to α ‐iminophosphonates, offering a robust and operationally convenient alternative to conventional asymmetric hydrogenation (AH) approaches.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Pierre Plouard"
    },
    {
      "name": "Laura Borrel"
    },
    {
      "name": "Pierre-Olivier Butin"
    },
    {
      "name": "Paul Muller"
    },
    {
      "name": "Rémi Cherpitel"
    },
    {
      "name": "Séverine Loiseau"
    },
    {
      "name": "Ludovic Clarion"
    },
    {
      "name": "David Virieux"
    },
    {
      "name": "Tahar Ayad"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5avjxf6s7qfgr.bib",
  "cited_by": 1,
  "doi": "10.1002/chem.202502405",
  "fulltext_url": null,
  "id": "5avjxf6s7qfgr",
  "issns": [
    "0947-6539",
    "1521-3765"
  ],
  "landing_url": "https://hal.science/hal-05736156v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.cata"
    ],
    [
      "hal",
      "1.chim.ther"
    ],
    [
      "openalex",
      "1604|Asymmetric Hydrogenation and Catalysis"
    ]
  ],
  "openalex": "W4414083473",
  "pdf_url": "https://hal.science/hal-05736156/document",
  "pmcid": null,
  "pmid": "40926510",
  "published": "2026-09-02",
  "publisher": "Wiley-VCH Verlag",
  "ris": "https://research.draconitic.com/paper/5avjxf6s7qfgr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:27Z",
      "native_id": "hal-05736156",
      "source": "hal",
      "url": "https://hal.science/hal-05736156v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.cata",
      "subfield": "catalysis"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.ther",
      "subfield": "medicinal"
    }
  ],
  "title": "Ru‐Catalyzed Asymmetric Transfer Hydrogenation of α‐iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α‐Aminophosphonates",
  "title_text": "Ru‐Catalyzed Asymmetric Transfer Hydrogenation of α‐iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α‐Aminophosphonates",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:27Z",
  "url": "https://research.draconitic.com/paper/5avjxf6s7qfgr",
  "venue": "Chemistry - A European Journal",
  "versions": []
}