{
  "abstract": "INTRODUCTION: While Alzheimer's disease (AD) typically elicits progressive cognitive decline, some individuals with significant AD pathology maintain cognition. Understanding the neuronal underpinnings of such cognitive resilience would propel the development of interventions for delaying dementia. METHODS: We used Barnes Maze testing to identify cognitively resilient 13-month-old TgF344-AD rats (established AD) and their non-transgenic littermates, followed by Neuropixels recording from 8500 neurons during repeated somatosensory stimulation, and culminating in post mortem tau and amyloid load quantifications. RESULTS: Cognitively resilient TgF344-AD rats recruited fewer neurons and displayed more stable neuronal representations during repeated stimulations in cortical excitatory and hippocampal inhibitory ensembles, with reduced excitatory spike burstiness and a distinct pattern of functional synaptic connectivity. These associations existed independently of amyloid levels. DISCUSSION: For the first time, our study revealed neuronal population-level hallmarks of maintained cognition that may serve as a novel neurophysiological biomarker of cognitive resilience and a target for stabilizing cognition.",
  "abstract_shown": true,
  "affiliations": [
    "Hurvitz Brain Sciences Sunnybrook Health Sciences Centre Toronto Ontario Canada",
    "Physical Sciences Sunnybrook Research Institute Toronto Ontario Canada",
    "Department of Medical Biophysics University of Toronto Toronto Ontario Canada",
    "Faculty of Health Sciences McMaster University Hamilton Ontario Canada",
    "Biological Sciences Sunnybrook Research Institute Toronto Ontario Canada",
    "Harquail Centre for Neuromodulation Sunnybrook Health Sciences Centre Toronto Ontario Canada",
    "Department of Obstetrics & Gynecology University of Toronto Toronto Ontario Canada",
    "Mouse Imaging Centre The Hospital for Sick Children Toronto Ontario Canada",
    "Translational Medicine SickKids Research Institute Toronto Ontario Canada",
    "Department of Laboratory Medicine and Pathobiology Temerty Faculty of Medicine University of Toronto Toronto Ontario Canada"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Keying Chen",
      "orcid": "0009-0003-3713-6382"
    },
    {
      "affs": [
        2,
        0,
        1
      ],
      "name": "Emma Pineau"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Margaret M. Koletar",
      "orcid": "0000-0003-4464-3887"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Andrea Trevisiol",
      "orcid": "0000-0002-7265-3639"
    },
    {
      "affs": [
        3
      ],
      "name": "Jie He",
      "orcid": "0000-0001-9541-4414"
    },
    {
      "affs": [
        4,
        0
      ],
      "name": "Mary Hill"
    },
    {
      "affs": [
        2,
        5,
        0,
        1
      ],
      "name": "Maged Goubran",
      "orcid": "0000-0001-5880-0818"
    },
    {
      "affs": [
        2,
        6,
        7,
        8
      ],
      "name": "John G. Sled",
      "orcid": "0000-0002-4461-283X"
    },
    {
      "affs": [
        4,
        9,
        0
      ],
      "name": "JoAnne McLaurin",
      "orcid": "0000-0002-7428-9105"
    },
    {
      "affs": [
        2,
        0,
        1
      ],
      "name": "Bojana Stefanovic",
      "orcid": "0000-0002-8439-7601"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5b2mvgd8hgaya.bib",
  "cited_by": 5,
  "doi": "10.1002/alz.71570",
  "fulltext_url": null,
  "id": "5b2mvgd8hgaya",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71570",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7163807529",
  "pdf_url": null,
  "pmcid": "PMC12713603",
  "pmid": "41427410",
  "published": "2026-06-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/5b2mvgd8hgaya.ris",
  "sources": [
    {
      "first_seen": "2026-11-11T13:20:33Z",
      "native_id": "W7163807529",
      "source": "openalex",
      "url": "https://doi.org/10.1002/alz.71570"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Alzheimer's disease research and treatments",
      "subfield": "neuroscience"
    }
  ],
  "title": "Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology",
  "title_text": "Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T13:21:09Z",
  "url": "https://research.draconitic.com/paper/5b2mvgd8hgaya",
  "venue": "Alzheimer s & Dementia",
  "versions": []
}