{
  "abstract": "Life expectancy has steadily increased over the past century, as has the occurrence of age-related diseases, most notably myocardial diseases. Aging is often accompanied by increased low-grade chronic inflammation, accumulation of terminally differentiated T-cells poised with proinflammatory phenotypes, and clonal hematopoiesis. These systemic alterations have been consistently shown to impact myocardial physiology, individual susceptibility to heart diseases and long-term heart disease prognosis. In recent years, progress has been made in understanding the interindividual (cross-sectional) and intraindividual (longitudinal) variability in the global immunosenescence profile, and novel immune-aging metric-based scoring systems bearing potential to predict cardiovascular events have emerged. We herein suggest that monitoring the patients’ individual immunosenescence trajectories, in addition to the classic cardiological work-up, could provide valuable diagnostic/prognostic information. Similarly, we propose that basic research in cardio-immunology could attain a deeper mechanistic understanding of age-related diseases and a more meaningful translational impact if the ‘aging context’ was embraced more systematically.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Marc Appel"
    },
    {
      "name": "Stefan Frantz"
    },
    {
      "name": "Gustavo Campos Ramos"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5b3gs66dynyey.bib",
  "cited_by": 9,
  "doi": "10.1016/j.cophys.2020.09.006",
  "fulltext_url": null,
  "id": "5b3gs66dynyey",
  "issns": [
    "2468-8681",
    "2468-8673"
  ],
  "landing_url": "https://hal.science/hal-05780796v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2705|Cardiac Fibrosis and Remodeling"
    ]
  ],
  "openalex": "W3097646291",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2468867320301115/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5b3gs66dynyey.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "hal-05780796",
      "source": "hal",
      "url": "https://hal.science/hal-05780796v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Fibrosis and Remodeling",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Myocardial inflammation comes of age",
  "title_text": "Myocardial inflammation comes of age",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/5b3gs66dynyey",
  "venue": "Current Opinion in Physiology",
  "versions": []
}