{
  "abstract": "Background Acute graft-vs.-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), where allogeneic donor T cells recognize recipient tissues as foreign and damage them. Gut microbiota disruption following allo-HCT has been associated with increased aGvHD incidence, severity, and mortality. Growing clinical evidence suggests the efficacy of fecal microbiotherapy to restore a healthy and diverse gut microbiota and to treat aGvHD. MaaT013 (Xervyteg ® ), a standardized allogeneic fecal microbiotherapy derived from pooled healthy human fecal microbiota, has demonstrated efficacy in mitigating steroid-refractory aGvHD in the Phase 2 HERACLES trial, and is currently being evaluated in the pivotal ARES trial in ruxolitinib-resistant aGvHD with gastrointestinal involvement. Methods Here, multi-omics analyses across complementary in vitro and in vivo models suggest that MaaT013 modulates biological processes involved in aGvHD pathogenesis. Results First, MaaT013-derived metabolites prevented inflammation-induced gut barrier alteration in an in vitro leaky gut model. Second, MaaT013 stimulated dendritic cell-mediated Tregs amplification and subsequent release of IL-10 and TGF-b in vitro . Third, beneficial bacteria from MaaT013 engrafted in the gut of germ-free mice, producing anti-inflammatory metabolites and restoring healthy gut physiology through immune rebalancing. Finally, MaaT013 delayed the appearance of aGvHD symptoms in a specific-pathogen free xenogeneic mouse model of aGvHD. Discussion Together, these results provide exploratory, multi-model evidence of MaaT013's potential to mitigate aGvHD by restoring microbial diversity, gut integrity, and immune homeostasis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Bastien Laperrousaz"
    },
    {
      "name": "Julie Reygner"
    },
    {
      "name": "Margaux de Seilhac"
    },
    {
      "name": "Antoine Sabourin"
    },
    {
      "name": "Cassandra Bompard"
    },
    {
      "name": "Cyrielle Gasc"
    },
    {
      "name": "Emmanuel Prestat"
    },
    {
      "name": "Benoît Levast"
    },
    {
      "name": "Charlotte Petitjean"
    },
    {
      "name": "Sophie Declomesnil"
    },
    {
      "name": "Emmanuelle Godefroy"
    },
    {
      "name": "Carole Schwintner"
    },
    {
      "name": "Nathalie Corvaïa"
    },
    {
      "name": "Robert Jenq"
    },
    {
      "name": "Ernst Holler"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5b5zn3xd8d29f.bib",
  "cited_by": 0,
  "doi": "10.3389/fmicb.2026.1920614",
  "fulltext_url": null,
  "id": "5b5zn3xd8d29f",
  "issns": [
    "1664-302X",
    "1664-302X"
  ],
  "landing_url": "https://inserm.hal.science/inserm-05777958v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W7213005075",
  "pdf_url": "https://inserm.hal.science/inserm-05777958/document",
  "pmcid": null,
  "pmid": "42807830",
  "published": "2026-09-14",
  "publisher": "Frontiers Media",
  "ris": "https://research.draconitic.com/paper/5b5zn3xd8d29f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:47Z",
      "native_id": "inserm-05777958",
      "source": "hal",
      "url": "https://inserm.hal.science/inserm-05777958v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-302X",
      "subfield": "microbiology"
    }
  ],
  "title": "MaaT013 fecal microbiotherapy modulates key gastro-intestinal and immunological processes involved in GvHD pathogenesis in vitro and in vivo",
  "title_text": "MaaT013 fecal microbiotherapy modulates key gastro-intestinal and immunological processes involved in GvHD pathogenesis in vitro and in vivo",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:47Z",
  "url": "https://research.draconitic.com/paper/5b5zn3xd8d29f",
  "venue": "Frontiers in Microbiology",
  "versions": []
}