{
  "abstract": "Flagellin is amongst the most abundant proteins in flagellated bacterial species and constitutes the major building block of the flagellar filament. The proteins FliW and FliS serve in the post-transcriptional control of flagellin and guide the protein to the flagellar type III secretion system (fT3SS), respectively. Here, we present the high-resolution structure of FliS/flagellin heterodimer and show that FliS and FliW bind to opposing interfaces located at the N- and C-termini of flagellin. The FliS/flagellin/FliW heterotrimer is able to interact with FlhA-C suggesting that FliW and FliS are released during flagellin export. After release, FliW and FliS are recycled to execute a new round of post-transcriptional regulation and targeting. Taken together, our study provides a mechanism explaining how FliW and FliS synchronize the production of flagellin with the capacity of the fT3SS to secrete flagellin.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Florian Altegoer"
    },
    {
      "name": "Sampriti Mukherjee"
    },
    {
      "name": "Wieland Steinchen"
    },
    {
      "name": "Patricia Bedrunka"
    },
    {
      "name": "Uwe Linne"
    },
    {
      "name": "Daniel B. Kearns"
    },
    {
      "name": "Gert Bange"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5b7n78pxk71ny.bib",
  "cited_by": 25,
  "doi": "10.1038/s41598-018-29884-8",
  "fulltext_url": null,
  "id": "5b7n78pxk71ny",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://hal.science/hal-05780536v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bbm"
    ],
    [
      "hal",
      "2.sdv.bbm.bs"
    ],
    [
      "openalex",
      "1311|Bacterial Genetics and Biotechnology"
    ]
  ],
  "openalex": "W2884189138",
  "pdf_url": "https://www.nature.com/articles/s41598-018-29884-8.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/5b7n78pxk71ny.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:48Z",
      "native_id": "hal-05780536",
      "source": "hal",
      "url": "https://hal.science/hal-05780536v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "hal:2.sdv.bbm.bs",
      "subfield": "structural-biology"
    },
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis",
  "title_text": "FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:48Z",
  "url": "https://research.draconitic.com/paper/5b7n78pxk71ny",
  "venue": "Scientific Reports",
  "versions": []
}