{
  "abstract": "PURPOSE: To evaluate the feasibility, reproducibility, and clinical outcomes of an image-guided, urethra-sparing transperineal radiofrequency ablation (TPTA) strategy for benign prostatic hyperplasia (BPH) in an outpatient interventional radiology setting.\n\nMETHODS: This was a prospective, bicenter, non-randomized study of consecutive men with moderate-to-severe lower urinary tract symptoms (LUTS) refractory or intolerant to medication treated with ultrasound-guided, urethra-sparing TPTA. Outcomes included the International Prostate Symptom Score (IPSS), quality of life, maximum urinary flow rate (Qmax), post-void residual volume (PVR), prostate volume, prostate-specific antigen (PSA), and ejaculatory function [assessed using the Male Sexual Health Questionnaire–Ejaculatory Dysfunction Short Form (MSHQ-EjD-SF)]; complications were graded using the Clavien–Dindo classification. The primary endpoint was a 12-month change in ejaculatory function; secondary endpoints included composite clinical response (≥ 30% IPSS reduction without retreatment) and urinary and structural changes.\n\nRESULTS: At 12 months, clinically meaningful improvements were observed across patient-reported symptoms and concordant objective functional and anatomical parameters in a carefully selected outpatient cohort. The median IPSS decreased from 19.5 at baseline to 5.0 at 6 months and 4.0 at 12 months (P < 0.001), accompanied by sustained increases in the Qmax and reductions in PVR, prostate volume, and PSA (all P < 0.001). Among sexually active men, MSHQ-EjD-SF function scores remained stable during the follow-up period, and antegrade ejaculation was preserved in 90% of patients. The composite clinical response rate (≥ 30% IPSS reduction without retreatment) was 97.1% at both 6 and 12 months, with no device-related Clavien–Dindo ≥ III complications observed.\n\nCONCLUSION: These findings suggest that image-guided, urethra-sparing TPTA is a reproducible outpatient interventional radiology procedure capable of achieving clinically meaningful symptom relief while preserving ejaculatory function, supporting further comparative and multicenter evaluation.\n\nCLINICAL SIGNIFICANCE: Urethra-sparing TPTA has proven to be a safe, feasible, and effective treatment for LUTS and may represent a minimally invasive and effective alternative for BPH.",
  "abstract_shown": true,
  "affiliations": [
    "Interventix, Rua Dr. Antônio Alves Arantes, Campo Grande, Brazil",
    "Paulista School of Medicine – Federal University of São Paulo (UNIFESP), Department of Diagnostic Imaging, São Paulo, Brazil",
    "Hospital Sírio-Libanês, Clinic of Radiology, São Paulo, SP, Brazil",
    "University of Florida Faculty of Medicine, Department of Radiology, Division of Vascular and Interventional Radiology, Jacksonville, United States of America",
    "Uberlandia Medical Center, Clinic of Radiology, Uberlândia, Brazil",
    "Associate Professor Hospital das Clínicas, University of São Paulo Medical School (HC-FMUSP), Urologist and Medical Director, Hospital Sírio-Libanês, São Paulo, Brazil"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Thiago Franchi Nunes",
      "orcid": "0000-0003-0006-3725"
    },
    {
      "affs": [
        1
      ],
      "name": "Denis Szejnfeld",
      "orcid": "0000-0001-8482-5955"
    },
    {
      "affs": [
        2
      ],
      "name": "Públio Cesar Cavalcante Viana",
      "orcid": "0000-0002-3155-3738"
    },
    {
      "affs": [
        0
      ],
      "name": "Flávio Scavone Stefanini",
      "orcid": "0000-0002-0738-177X"
    },
    {
      "affs": [
        3
      ],
      "name": "Vinicius Adami Vayego Fornazari",
      "orcid": "0000-0002-5880-1703"
    },
    {
      "affs": [
        4
      ],
      "name": "Túlio Fabiano de Oliveira Leite",
      "orcid": "0000-0001-9427-5897"
    },
    {
      "affs": [
        5
      ],
      "name": "Alvaro Sadek Sarkis",
      "orcid": "0009-0002-2312-1967"
    },
    {
      "affs": [
        0
      ],
      "name": "Hugo Alexandre Socrates de Castro",
      "orcid": "0000-0001-9593-0654"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5b8zzt0v7pd13.bib",
  "cited_by": 2,
  "doi": "10.4274/dir.2026.263745",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725031/",
  "id": "5b8zzt0v7pd13",
  "issns": [
    "1305-3825",
    "1305-3612"
  ],
  "landing_url": "https://doi.org/10.4274/dir.2026.263745",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Interventional Radiology - Original Article"
    ],
    [
      "openalex",
      "2748|Urinary Bladder and Prostate Research"
    ]
  ],
  "openalex": "W7133210296",
  "pdf_url": "https://dirjournal.org/pdf/beb8919b-f013-4ea1-b1c8-40332e840fe1/articles/dir.2026.263745/2026.263745.pdf",
  "pmcid": "PMC13725031",
  "pmid": "41766288",
  "published": "2026-11-02",
  "publisher": "Turkish Society of Radiology",
  "ris": "https://research.draconitic.com/paper/5b8zzt0v7pd13.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:30Z",
      "native_id": "PMC13725031",
      "source": "pmc",
      "url": "https://doi.org/10.4274/dir.2026.263745"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Urinary Bladder and Prostate Research",
      "subfield": "general"
    }
  ],
  "title": "Image-guided, urethra-sparing transperineal radiofrequency ablation for benign prostatic hyperplasia: a prospective bicenter outpatient study",
  "title_text": "Image-guided, urethra-sparing transperineal radiofrequency ablation for benign prostatic hyperplasia: a prospective bicenter outpatient study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:23Z",
  "url": "https://research.draconitic.com/paper/5b8zzt0v7pd13",
  "venue": "Diagnostic and Interventional Radiology",
  "versions": []
}