{
  "abstract": "BACKGROUND: Despite affecting 2-4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report the first international randomised double-blind, sham-controlled trial developed to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) as an add-on therapy for fibromyalgia. METHODS: , or sham stimulation. This included 10 induction sessions over 2 weeks, followed by weekly maintenance (6 weeks), and fortnightly extended maintenance (8 weeks). Primary outcome was ≥50% pain reduction at week 8 compared with baseline. Secondary outcomes included pain interference, mood, global impression of change, and Fibromyalgia Impact Questionnaire (FIQ) scores at weeks 8 and 16. RESULTS: We randomised 101 women (mean age 48 [range 25-83] yr) into active (n=52) or sham (n=49) arms. Bayesian analysis revealed a 99.4% probability of ≥50% pain reduction at week 8 in the active group vs sham (odds ratio [OR] 3.04; 95% credible interval [95% CrI] 1.26-8.06), with a number needed to treat of 4.54. Frequentist analysis confirmed that relative pain reduction was higher in the active than in the sham group (40.4% vs 18.4%, P=0.028). At week 16, this probability reduced to 34.2% (OR 0.815; 95% CrI 0.313-2.1), but the likelihood of FIQ score reduction was 79.1%. The intervention appeared safe. CONCLUSIONS: Add-on M1-repetitive transcranial magnetic stimulation reduced pain intensity up to 8 weeks in women with fibromyalgia. Although analgesic effects waned, functional improvements remained during extended maintenance at week 16.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "name": "Valquíria A. Silva"
    },
    {
      "name": "Abrahão F. Baptista"
    },
    {
      "name": "Alessandra S. Fonseca"
    },
    {
      "name": "Adriana M. Carneiro"
    },
    {
      "name": "André R. Brunoni"
    },
    {
      "name": "Paulo.E.M. Carrilho"
    },
    {
      "name": "Catarina C. Lins"
    },
    {
      "name": "Gabriel T. Kubota"
    },
    {
      "name": "Ana Mércia B.L. Fernandes"
    },
    {
      "name": "Jorge.D.S. Lapa"
    },
    {
      "name": "Lucas M. dos Santos"
    },
    {
      "name": "Ivo Sasso"
    },
    {
      "name": "Katia Monte-Silva"
    },
    {
      "name": "Frédérique Poindessous-Jazat"
    },
    {
      "name": "Nobuhiko Mori"
    },
    {
      "name": "Kenji Miki"
    },
    {
      "name": "Adriana Baltar"
    },
    {
      "name": "Clarice Tanaka"
    },
    {
      "name": "Manoel J. Teixeira"
    },
    {
      "name": "Koichi Hosomi"
    },
    {
      "name": "Didier Bouhassira"
    },
    {
      "name": "Nadine Attal"
    },
    {
      "name": "Daniel Ciampi de Andrade"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5bw0nwxhtr6w9.bib",
  "cited_by": 20,
  "doi": "10.1016/j.bja.2024.12.045",
  "fulltext_url": null,
  "id": "5bw0nwxhtr6w9",
  "issns": [
    "0007-0912",
    "1471-6771"
  ],
  "landing_url": "https://hal.science/hal-05851900v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "openalex",
      "2808|Transcranial Magnetic Stimulation Studies"
    ]
  ],
  "openalex": "W4408391928",
  "pdf_url": "https://www.bjanaesthesia.org/article/S0007-0912(25)00102-3/pdf",
  "pmcid": null,
  "pmid": "40087077",
  "published": "2026-11-04",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/5bw0nwxhtr6w9.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:20:13Z",
      "native_id": "hal-05851900",
      "source": "hal",
      "url": "https://hal.science/hal-05851900v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    }
  ],
  "title": "Motor cortex repetitive transcranial magnetic stimulation in fibromyalgia: a multicentre randomised controlled trial",
  "title_text": "Motor cortex repetitive transcranial magnetic stimulation in fibromyalgia: a multicentre randomised controlled trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:44Z",
  "url": "https://research.draconitic.com/paper/5bw0nwxhtr6w9",
  "venue": "British Journal of Anaesthesia",
  "versions": []
}