{
  "abstract": "Objective\n\nTo evaluate the association of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with delayed wound healing after anal fistula surgery and to develop a combined risk prediction model.Methods\n\nClinical data from 362 patients with anal fistula who underwent surgery between January 2022 and December 2024 were retrospectively analyzed. Patients were divided into a delayed healing group (>28 days, n=65) and a non-delayed healing group (≤28 days, n=297). Spearman correlation was used to assess the relationships between NLR, PLR, and healing time. LASSO regression was used for variable selection, and prespecified clinically important variables were forced into the final multivariable logistic regression model to identify independent risk factors. ROC curves were constructed to evaluate the predictive performance of NLR and PLR.Results\n\nPreoperative NLR, PLR, and fasting blood glucose (FBG) were higher in the delayed healing group (all P<0.01), whereas albumin (Alb) was lower (P<0.001). NLR and PLR were positively correlated with healing time (r=0.199 and 0.242). Age (OR=1.044), wound area (OR=3.142), NLR (OR=2.369), PLR (OR=1.015), and FBG (OR=1.803) were independent risk factors, while Alb (OR=0.866) was protective (all P<0.05). The AUCs were 0.735 for NLR and 0.712 for PLR. The combined nomogram model achieved an AUC of 0.919 (95% CI: 0.880-0.957), with a bias-corrected AUC of 0.910 after bootstrap internal validation (1000 resamples), acceptable calibration (Hosmer-Lemeshow P = 0.057), and potential clinical utility in this cohort.Conclusion\n\nPreoperative NLR and PLR were independently associated with delayed wound healing. The nomogram incorporating these and other factors showed moderate predictive value, was internally validated, and requires external validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anorectal, Xiangtan Hospital of Traditional Chinese Medicine, Xiangtan, Hunan, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ting Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tao He"
    },
    {
      "affs": [
        0
      ],
      "name": "Aiping Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Mao Pi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5c1faz23n3tm7.bib",
  "cited_by": 0,
  "doi": "10.2147/jmdh.s629310",
  "fulltext_url": "https://europepmc.org/articles/PMC13712222",
  "id": "5c1faz23n3tm7",
  "issns": [
    "1178-2390"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948687",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7223385404",
  "pdf_url": "https://europepmc.org/articles/PMC13712222?pdf=render",
  "pmcid": "PMC13712222",
  "pmid": "42948687",
  "published": "2026-10-23",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/5c1faz23n3tm7.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42948687",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948687"
    },
    {
      "first_seen": "2026-10-31T12:22:51Z",
      "native_id": "PMC13712222",
      "source": "pmc",
      "url": "https://doi.org/10.2147/jmdh.s629310"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Predictors of Delayed Wound Healing After Anal Fistula Surgery: A Retrospective Study.",
  "title_text": "Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Predictors of Delayed Wound Healing After Anal Fistula Surgery: A Retrospective Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:51Z",
  "url": "https://research.draconitic.com/paper/5c1faz23n3tm7",
  "venue": "Journal of multidisciplinary healthcare",
  "versions": []
}