{
  "abstract": "COVID-19 has been associated with reproductive dysfunction, although the underlying mechanisms remain unclear. Here, we investigated the effects of inactivated SARS-CoV-2 (iSARS-CoV-2) exposure on reproductive outcomes in K18-hACE2 mice. Pregnant females exposed during early gestation showed reduced fetal number, increased resorptions and decreased placental efficiency. These alterations were associated with pulmonary inflammation, characterized by elevated TNF-α, IL-6 and IFN-γ levels and histopathological damage. In males, exposure impaired the sperm count, motility and reproductive performance, and negatively affected pregnancy outcomes in untreated females. Notably, inflammatory responses occurred in the absence of viral replication, indicating that viral components can trigger systemic effects. Together, these findings demonstrate that inactivated SARS-CoV-2 induces inflammation that compromises fertility and gestational success in both sexes.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratório de Farmacologia da Dor e da Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.",
    "Laboratório de Toxicologia Ambiental, Departamento de Ciências Biológicas, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro 21041-210, Brazil.",
    "Coordenação de Atividades com Modelos Biológicos Experimentais, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.",
    "Departamento de Ciências Naturais da Terra, Universidade do Estado de Minas Gerais, Belo Horizonte 35501-170, Brazil.",
    "Departamento de Microbiologia, Instituto de Ciências Biomédicas, Laboratório de Virologia Básica e Aplicada, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Patrícia Ribeiro de Carvalho França",
      "orcid": "0000-0001-7661-7726"
    },
    {
      "affs": [
        0
      ],
      "name": "João Pedro Barros de Paiva"
    },
    {
      "affs": [
        0
      ],
      "name": "Amanda Gabriel Valente",
      "orcid": "0000-0002-0395-6935"
    },
    {
      "affs": [
        0
      ],
      "name": "Alan Silva Minho"
    },
    {
      "affs": [
        0
      ],
      "name": "Renato Sampaio Carvalho"
    },
    {
      "affs": [
        1
      ],
      "name": "Rosangela Ribeiro de Carvalho"
    },
    {
      "affs": [
        2
      ],
      "name": "Luiz Ricardo Berbert"
    },
    {
      "affs": [
        2
      ],
      "name": "Marcel Frajblat"
    },
    {
      "affs": [
        3
      ],
      "name": "Maria Marta Figueiredo",
      "orcid": "0000-0003-2538-5878"
    },
    {
      "affs": [
        4
      ],
      "name": "Daisymara Priscila de Almeida Marques"
    },
    {
      "affs": [
        4
      ],
      "name": "Jordana Grazziela Alves Coelho-Dos-Reis",
      "orcid": "0000-0002-2360-1875"
    },
    {
      "affs": [
        0
      ],
      "name": "Patricia Dias Fernandes",
      "orcid": "0000-0001-6870-6745"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5c2dqb9vhfgxw.bib",
  "cited_by": 0,
  "doi": "10.3390/v18101112",
  "fulltext_url": "https://europepmc.org/articles/PMC13709564",
  "id": "5c2dqb9vhfgxw",
  "issns": [
    "1999-4915"
  ],
  "landing_url": "https://europepmc.org/article/MED/42944032",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|COVID-19 Impact on Reproduction"
    ]
  ],
  "openalex": "W7221048965",
  "pdf_url": "https://europepmc.org/articles/PMC13709564?pdf=render",
  "pmcid": "PMC13709564",
  "pmid": "42944032",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5c2dqb9vhfgxw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42944032",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42944032"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|COVID-19 Impact on Reproduction",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Inactivated SARS-CoV-2 Exposure Induces Inflammation and Impairs Reproductive Outcomes in Mice.",
  "title_text": "Inactivated SARS-CoV-2 Exposure Induces Inflammation and Impairs Reproductive Outcomes in Mice.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/5c2dqb9vhfgxw",
  "venue": "Viruses",
  "versions": []
}