{
  "abstract": "Drug resistance remains a major burden in clinical care, often emerging from a subpopulation of cells in a drug-tolerant state. In this study, we aimed to characterize the transcriptional features of persistent non-small cell lung cancer (NSCLC) cells following cisplatin-pemetrexed chemotherapy and explore the therapeutic potency of oncolytic viruses to eliminate these cells. We established a 3D spheroid model of NSCLC and applied long-term chemotherapy to induce a reversible, non-proliferative persistent state associated with lower sensitivity to treatment. Single-cell RNA sequencing coupled with comparative analysis of multiple human datasets sheds light on a core transcriptional signature of persistence. This signature was enriched in patient-derived minimal residual disease (MRD) datasets, highlighting the clinical relevance of persistent preclinical models. Furthermore, transcriptomic analyses suggested a vulnerability of persister cells to oncolytic viruses, a finding validated in spheroid and patient-derived organoids. Altogether, these results define a conserved persistence signature and support the use of virotherapy as a promising option to target MRD.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Clara Fauveau"
    },
    {
      "name": "Emily Lawendy"
    },
    {
      "name": "Jules Deforges"
    },
    {
      "name": "Sandrine Cochin"
    },
    {
      "name": "Baptiste Moreau"
    },
    {
      "name": "Jean-Marc Balloul"
    },
    {
      "name": "Philippe Erbs"
    },
    {
      "name": "Shreyansh Jain"
    },
    {
      "name": "Gilles Laverny"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5cwrgggd5ck6j.bib",
  "cited_by": 0,
  "doi": "10.1016/j.omton.2026.201279",
  "fulltext_url": null,
  "id": "5cwrgggd5ck6j",
  "issns": [
    "2950-3299"
  ],
  "landing_url": "https://univoak.hal.science/hal-05758136v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bbm"
    ],
    [
      "hal",
      "1.sdv.can"
    ],
    [
      "openalex",
      "1311|Virus-based gene therapy research"
    ]
  ],
  "openalex": "W7165393507",
  "pdf_url": "https://univoak.hal.science/hal-05758136/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-07",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/5cwrgggd5ck6j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:37Z",
      "native_id": "hal-05758136",
      "source": "hal",
      "url": "https://univoak.hal.science/hal-05758136v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "hal:1.sdv.bbm",
      "subfield": "general"
    },
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.can",
      "subfield": "oncology"
    }
  ],
  "title": "Dissecting residual disease in spheroids reveals pan-cancer persistence signatures and a therapeutic window for oncolytic viruses",
  "title_text": "Dissecting residual disease in spheroids reveals pan-cancer persistence signatures and a therapeutic window for oncolytic viruses",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/5cwrgggd5ck6j",
  "venue": "Molecular Therapy: Oncology",
  "versions": []
}