{
  "abstract": "The human subcortex integrates information from distributed cortical regions through functionally organized cortico-subcortical systems. Using the publicly available MICA-MICs multimodal MRI dataset of 50 healthy adults, we characterized the microstructural organization of functionally converging cortical regions. First, using resting-state fMRI., we identified cortical regions converging on subcortical targets, including thalamic, basal ganglia, and subcortical limbic structures. Then, using depth-resolved quantitative T1 profiles, we constructed a convergence-restricted microstructural profile covariance matrix, followed by diffusion-map embedding. The first microstructural gradient predominantly differentiated primary and association cortex, whereas the second gradient showed target-related differentiation beyond differences in primary versus association cortex. Cytoarchitectural analysis further revealed target-related differences in cortical composition. Together, these findings reveal complementary dimensions of cortico-subcortical functional organization, spanning broad cortical hierarchy, target-related microstructural differentiation, and cytoarchitectural composition.",
  "abstract_shown": true,
  "affiliations": [
    "Indian Institute of Technology Jodhpur"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "P. Verma"
    },
    {
      "name": "S. Singh"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Dang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5dhvmfa1anwh7.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.02.756182",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.02.756182v1.full",
  "id": "5dhvmfa1anwh7",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.02.756182v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2741|Advanced Neuroimaging Techniques and Applications"
    ]
  ],
  "openalex": "W7219795508",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.02.756182v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5dhvmfa1anwh7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:34Z",
      "native_id": "10.64898/2026.10.02.756182",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.02.756182v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "MICROSTRUCTURAL ORGANIZATION OF CORTICO-SUBCORTICAL FUNCTIONAL CONVERGENCE",
  "title_text": "MICROSTRUCTURAL ORGANIZATION OF CORTICO-SUBCORTICAL FUNCTIONAL CONVERGENCE",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:34Z",
  "url": "https://research.draconitic.com/paper/5dhvmfa1anwh7",
  "venue": "bioRxiv",
  "versions": []
}