{
  "abstract": "Purpose: Chronic hip pain after total hip replacement (THR) poses a diagnostic challenge and frequently yields lengthy and unsatisfactory diagnostic work-up. This study aims to evaluate the diagnostic role and clinical impact of [18F]FDG PET/MRI compared with regular diagnostic work-up in patients with chronic hip pain after THR.\n\nMethods: In this randomized study, 20 patients with persistent hip pain of unclear origin after THR underwent either PET/MRI-guided clinical management or regular diagnostic work-up. Additional diagnostic and therapeutic procedures during 12-month follow-up were recorded and a final expert diagnosis was determined through expert opinion based on all available information. Patient reported outcomes included pain scores, functional scores and quality of life.\n\nResults: In the PET/MRI group, a final expert diagnosis could be established for 8/10 patients compared to 5/10 in the control group. PET-MRI contributed to this diagnosis in 7 of 10 patients by identifying 5 new pain sources, confirming 3 clinically suspected pain sources, and excluding 1 clinically suspected pain source. At 6 months, mean pain scores on NRS 0–10 decreased in both groups (PET/MRI: 6.1 to 5.2; control: 5.2 to 3.4). Between-group differences could not be statistically tested due to insufficient statistical power.\n\nConclusion: Initial results demonstrate the potential of [18F]FDG PET/MRI for the identification of pain sources in patients with diagnostically challenging chronic hip pain after THR. Further research regarding clinical outcome is warranted in a larger cohort with standardized treatment strategies incorporating PET/MRI findings.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00259-026-08142-4.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands",
    "Department of Orthopaedics & Sports Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands",
    "Department of Radiology, University of Wisconsin-Madison, Madison, WI USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jacob M. Mostert",
      "orcid": "0000-0003-1347-411X"
    },
    {
      "affs": [
        1
      ],
      "name": "Pieter K. Bos",
      "orcid": "0000-0001-9285-2320"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael Ananta"
    },
    {
      "affs": [
        0
      ],
      "name": "Galied S. R. Muradin",
      "orcid": "0000-0002-2632-9387"
    },
    {
      "affs": [
        2
      ],
      "name": "Sandip Biswal",
      "orcid": "0000-0002-3421-0853"
    },
    {
      "affs": [
        0
      ],
      "name": "Edwin H.G. Oei",
      "orcid": "0000-0003-3727-3427"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Rianne A. van der Heijden",
      "orcid": "0000-0001-6964-2536"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5dk8ydvdyn0ms.bib",
  "cited_by": 0,
  "doi": "10.1007/s00259-026-08142-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13727810/",
  "id": "5dk8ydvdyn0ms",
  "issns": [
    "1619-7070",
    "1619-7089"
  ],
  "landing_url": "https://doi.org/10.1007/s00259-026-08142-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Orthopaedic implants and arthroplasty"
    ]
  ],
  "openalex": "W7203948381",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00259-026-08142-4.pdf",
  "pmcid": "PMC13727810",
  "pmid": "42629492",
  "published": "2026-08-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5dk8ydvdyn0ms.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:23:37Z",
      "native_id": "PMC13727810",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00259-026-08142-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Orthopaedic implants and arthroplasty",
      "subfield": "surgery"
    }
  ],
  "title": "The potential of [18F]FDG PET/MRI for identifying pain sources in patients with diagnostically challenging chronic hip pain after total hip replacement",
  "title_text": "The potential of [18F]FDG PET/MRI for identifying pain sources in patients with diagnostically challenging chronic hip pain after total hip replacement",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:55Z",
  "url": "https://research.draconitic.com/paper/5dk8ydvdyn0ms",
  "venue": "European Journal of Nuclear Medicine and Molecular Imaging",
  "versions": []
}