{
  "abstract": "Purpose\n\nEvidence is inconsistent regarding an association between alcohol consumption and survival following a breast cancer diagnosis; therefore, we examined how change in alcohol consumption affects all-cause mortality (ACM) in a population of breast cancer survivors.Methods\n\nWe prospectively assessed pre-diagnosis, pre- to post-diagnosis, and post-diagnosis change in alcohol consumption among 1,558 postmenopausal women (mean age-at-diagnosis: 71 years) diagnosed with non-metastatic invasive breast cancer from the American Cancer Society Cancer Prevention Study-II Nutrition Cohort (baseline: 1992-1993). Five categories of alcohol intake were determined at each assessment; change in alcohol consumption was categorized as stable, quit, reduced, and increased. Change occurred at a median of two years before (pre-diagnosis) and two years after (post-diagnosis) diagnosis. Cox proportional hazards regression was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the associations between change groups and ACM.Results\n\nOver a median follow-up of 12.6 years, 750 women died (130 breast cancer deaths). Compared to stable consumption, the association between cessation and ACM varied by change interval: pre-diagnosis (HR:0.91, CI:0.69-1.21), pre- to post-diagnosis: (HR:1.39, CI:1.12-1.73), post-diagnosis: (HR:0.98, CI:0.70-1.35). Alcohol reduction was not associated with ACM. Among women consuming ≥ 1 drink/day pre-diagnosis, increasing consumption elevated ACM risk (HR:1.83, 95%CI:1.02-3.31).Conclusion\n\nAlcohol reduction or cessation was not associated with a decrease in ACM among older breast cancer survivors. Among those drinking ≥ 1 drink/day, an increase in consumption pre-diagnosis was associated with higher mortality. Findings may be limited by uncontrolled confounding, a low prevalence of heavy drinking, or an insufficient duration of sustained change.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, 360 Hayes Road, Buffalo, NY, 14214, USA. ssmith67@buffalo.edu.",
    "Department of Population Health Sciences, British Columbia Cancer Research Institute, BC, Vancouver, Canada. ssmith67@buffalo.edu.",
    "Department of Population Science, American Cancer Society, Atlanta, GA, USA.",
    "Department of Actuarial Mathematics and Statistics, School of Mathematical and Computer Science, Heriot Watt University, Edinburgh, UK.",
    "Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, 360 Hayes Road, Buffalo, NY, 14214, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Samantha Rees",
      "orcid": "0000-0003-1466-9357"
    },
    {
      "affs": [
        2
      ],
      "name": "Clara Bodelon"
    },
    {
      "affs": [
        3
      ],
      "name": "Saptarshi Chakraborty"
    },
    {
      "affs": [
        4
      ],
      "name": "Amy E Millen"
    },
    {
      "affs": [
        2
      ],
      "name": "Ying Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Kierstin Faw"
    },
    {
      "affs": [
        2
      ],
      "name": "Lauren R Teras"
    },
    {
      "affs": [
        2
      ],
      "name": "Marissa M Shams-White"
    },
    {
      "affs": [
        2
      ],
      "name": "Alpa V Patel"
    },
    {
      "affs": [
        4
      ],
      "name": "Jo L Freudenheim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5dsffzsqz9d37.bib",
  "cited_by": 0,
  "doi": "10.1007/s10549-026-08113-1",
  "fulltext_url": "https://europepmc.org/articles/PMC13694358",
  "id": "5dsffzsqz9d37",
  "issns": [
    "0167-6806",
    "1573-7217"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909681",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Alcohol Consumption and Health Effects"
    ]
  ],
  "openalex": "W7223261819",
  "pdf_url": "https://europepmc.org/articles/PMC13694358?pdf=render",
  "pmcid": "PMC13694358",
  "pmid": "42909681",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5dsffzsqz9d37.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909681",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909681"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Alcohol Consumption and Health Effects",
      "subfield": "general"
    }
  ],
  "title": "Change in alcohol consumption and all-cause mortality among postmenopausal women diagnosed with breast cancer.",
  "title_text": "Change in alcohol consumption and all-cause mortality among postmenopausal women diagnosed with breast cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/5dsffzsqz9d37",
  "venue": "Breast cancer research and treatment",
  "versions": []
}