{
  "abstract": "Purpose: To evaluate the efficacy and safety of Adjunct Triamcinolone (TA) with the Susanna drainage device for refractory primary open-angle glaucoma, to our knowledge, the first such evaluation with a non-valved glaucoma drainage device.\n\nMethods: This prospective, multicenter, randomized, double-blind (patient and outcome assessor) trial included 39 eyes with refractory primary open-angle glaucoma, divided into a control (n = 20) and a triamcinolone group (n = 19). Primary outcome was mean Intraocular Pressure (IOP) at six months. Secondary outcomes included success rates and postoperative complications.\n\nResults: Baseline characteristics and mean preoperative IOP were similar (24.45±8.03 mmHg control vs. 24.95±6.80 mmHg TA, p = 0.83). At six months, both groups showed similar mean IOP reduction (14.05±3.99 mmHg control vs. 14.33±4.70 mmHg TA, p > 0.99), with percentage reductions of 42.53% and 42.56%, respectively. Hypotensive eyedrop use also decreased similarly (1.57 control vs. 1.16 TA, p = 0.95). Qualified success (IOP 5‒21 mmHg) was 90% (control) and 89.47% (TA) (p > 0.05). However, the triamcinolone group had a significantly higher incidence of late-onset hypotony (52.6%vs. 0%, p < 0.001). Clinically significant hypotony requiring surgical re-intervention occurred in 36.8% of the TA group versus 0% in the control group (p = 0.003).\n\nConclusion: In patients undergoing Susanna GDD implantation, adjunctive sub-Tenon triamcinolone provided no additional IOP-lowering benefit but was associated with a significantly increased risk of serious hypotony-related complications. Our findings do not support the use of sub-Tenon triamcinolone (20 mg) as an adjunct to non-valved GDDs in this setting.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil",
    "Fundação Altino Ventura (FAV), Recife, Pernambuco, Brazil"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marcus Vinicius Takatsu"
    },
    {
      "affs": [
        0
      ],
      "name": "Karin Chiaradia Takatsu"
    },
    {
      "affs": [
        1
      ],
      "name": "Kaio Santos Soares"
    },
    {
      "affs": [
        1
      ],
      "name": "Kayo Pinheiro Esposito"
    },
    {
      "affs": [
        0
      ],
      "name": "Leonardo Eleuterio Ariello"
    },
    {
      "affs": [
        0
      ],
      "name": "Renato Antunes Schiave Germano"
    },
    {
      "affs": [
        0
      ],
      "name": "Marcio Henrique Mendes"
    },
    {
      "affs": [
        0
      ],
      "name": "Aline Domingos Pinto Ruppert"
    },
    {
      "affs": [
        0
      ],
      "name": "Marcelo Hatanaka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5dv437vhrc9eb.bib",
  "cited_by": 0,
  "doi": "10.1016/j.clinsp.2026.101221",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733475/",
  "id": "5dv437vhrc9eb",
  "issns": [
    "1807-5932",
    "1980-5322"
  ],
  "landing_url": "https://doi.org/10.1016/j.clinsp.2026.101221",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Articles"
    ],
    [
      "openalex",
      "2731|Glaucoma and retinal disorders"
    ]
  ],
  "openalex": "W7224313273",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S1807593226003315/pdf",
  "pmcid": "PMC13733475",
  "pmid": "42956710",
  "published": "2026-10-30",
  "publisher": "Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo",
  "ris": "https://research.draconitic.com/paper/5dv437vhrc9eb.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:14Z",
      "native_id": "PMC13733475",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.clinsp.2026.101221"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Glaucoma and retinal disorders",
      "subfield": "general"
    }
  ],
  "title": "Adjunctive sub-tenon triamcinolone with Susanna glaucoma drainage device: a randomized clinical trial",
  "title_text": "Adjunctive sub-tenon triamcinolone with Susanna glaucoma drainage device: a randomized clinical trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:14Z",
  "url": "https://research.draconitic.com/paper/5dv437vhrc9eb",
  "venue": "Clinics",
  "versions": []
}