{
  "abstract": "Objective\n\nArterial serum was generally used to uncover shifts in the metabolic profile induced by surgery and anaesthesia. The specific perioperative metabolic alterations in the brain remain largely unknown. We aimed to detect perioperative changes in cerebral metabolism by arteriovenous gradients of circulating metabolites across the brain using liquid chromatography-tandem mass spectrometry (LC-MS) analysis.Methods\n\nThe prospective study was conducted at Sichuan Provincial People's Hospital, China. Twenty patients with unilateral pulmonary lesion were recruited. Patients undergoing thoracic surgery were randomised to receive general anaesthesia with sevoflurane or propofol. Blood samples from radial artery and jugular bulb were collected before and after first anaesthetic administration, at the end of 60 min of maintenance of anaesthesia and 60 min after patients regained consciousness. LC-MS-based untargeted metabolomics strategies were used to determine the difference in abundance of circulating metabolites between artery and jugular bulb.Results\n\nA total of 3900 metabolites were detected. Potential critical alterations of metabolites including phosphatidylcholine (PC), phosphatidylethanolamine (PE), choline, isocitrate and lactate and pathways were identified. Brain took up PC and PE in group sevoflurane but secreted these compounds in group propofol. Additionally, propofol was associated with the release of choline and isocitrate from brain. In both groups, lactic acid entered brain intraoperatively.Conclusion\n\nThis work may offer a comprehensive mapping of perioperative alterations of cerebral metabolism in patients under general anaesthesia and a new direction for further studies in pharmacology of general anaesthetics and pathogenesis of perioperative brain dysfunction. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2500111204.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China uestc.edu.cn.",
    "Department of Anesthesiology Wenjiang Hospital of Sichuan Provincial People's Hospital Chengdu Wenjiang District People's Hospital Chengdu China.",
    "Department of Stomatology Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China uestc.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chenghong Wang",
      "orcid": "0009-0006-9104-2864"
    },
    {
      "affs": [
        0
      ],
      "name": "Sike Ma",
      "orcid": "0009-0005-7791-7911"
    },
    {
      "affs": [
        0
      ],
      "name": "Xudan Xing",
      "orcid": "0009-0001-0468-1611"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Qian Liu",
      "orcid": "0009-0007-2881-5091"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Yang",
      "orcid": "0009-0007-1930-2198"
    },
    {
      "affs": [
        0
      ],
      "name": "Qian Lei",
      "orcid": "0000-0001-8647-1011"
    },
    {
      "affs": [
        2
      ],
      "name": "Juan Liao",
      "orcid": "0000-0002-3599-1348"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Li",
      "orcid": "0000-0002-5097-3244"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5e61cfxphy2g2.bib",
  "cited_by": 0,
  "doi": "10.1155/anrp/8559251",
  "fulltext_url": "https://europepmc.org/articles/PMC13693408",
  "id": "5e61cfxphy2g2",
  "issns": [
    "1687-6962",
    "1687-6970"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921174",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2703|Anesthesia and Sedative Agents"
    ]
  ],
  "openalex": "W7223292176",
  "pdf_url": "https://europepmc.org/articles/PMC13693408?pdf=render",
  "pmcid": "PMC13693408",
  "pmid": "42921174",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5e61cfxphy2g2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42921174",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921174"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Anesthesia and Sedative Agents",
      "subfield": "surgery"
    }
  ],
  "title": "Perioperative Cerebral Metabolism in Patients Under General Anaesthesia With Sevoflurane or Propofol: Evaluation of the Arterial and Jugular Bulb Metabolome.",
  "title_text": "Perioperative Cerebral Metabolism in Patients Under General Anaesthesia With Sevoflurane or Propofol: Evaluation of the Arterial and Jugular Bulb Metabolome.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/5e61cfxphy2g2",
  "venue": "Anesthesiology research and practice",
  "versions": []
}