{
  "abstract": "Type 2 diabetes (T2D) and osteoporosis (OP) frequently coexist, but the molecular features linking metabolic dysfunction to impaired bone remodeling remain incompletely defined. Here, we integrated public bulk transcriptomic datasets, a clinical serum proteomics cohort, and descriptive single-cell resources to prioritize candidates for investigation in a T2D-OP mouse model. The existing differential-expression screens, weighted gene co-expression network analysis (WGCNA) and set intersections nominated TTC1. A documented TTC1 expression-stratified GSEA in the low-versus-high BMD dataset was used for exploratory pathway context; it was not a disease-case-control enrichment analysis and did not apply a p-value adjustment method. These analyses are hypothesis-generating: TTC1 met the nominal screening criteria but did not meet BH-FDR < 0.05 in the low-versus-high BMD transcriptomic or serum proteomic results, and the T2D bulk analysis did not account for longitudinal sampling. Pre-imputation serum TTC1 measurements were available in only 1/14 controls and 6/14 patients, and TTC1 was excluded by detection-coverage filters. Single-cell analyses provided cellular context without cross-study disease-effect inference. In the T2D-OP mouse model, bone microstructural deterioration and histopathological damage were accompanied by increased TTC1, TNF-α, iNOS, NFATc1 and TRAP expression and reduced RUNX2 and OCN expression in bone tissue. The combined observations motivate further study of TTC1 in abnormal bone remodeling; independent clinical validation and functional perturbation are needed to establish its biological role.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Yu Zhao"
    },
    {
      "name": "Tra My Nguyen"
    },
    {
      "name": "Fan Wang"
    },
    {
      "name": "Yijin Li"
    },
    {
      "name": "Zhicong Xia"
    },
    {
      "name": "Yueping Cai"
    },
    {
      "name": "Lihua Chen"
    },
    {
      "name": "Xiaosheng Lin",
      "orcid": "0000-0003-1844-0410"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5e9phw91sq1bg.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-77685-1",
  "fulltext_url": null,
  "id": "5e9phw91sq1bg",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-77685-1",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Bone Metabolism and Diseases"
    ]
  ],
  "openalex": "W7212173985",
  "pdf_url": "https://www.nature.com/articles/s41598-026-77685-1_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/5e9phw91sq1bg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "10.1038/s41598-026-77685-1",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-77685-1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bone Metabolism and Diseases",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Molecular signatures of bone remodeling imbalance in type 2 diabetes and osteoporosis comorbidity: a multi-omics study with in vivo support",
  "title_text": "Molecular signatures of bone remodeling imbalance in type 2 diabetes and osteoporosis comorbidity: a multi-omics study with in vivo support",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/5e9phw91sq1bg",
  "venue": "Scientific Reports",
  "versions": []
}